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Research Proven Health Benefits:
The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.
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Bone health
a) Support healthy bone mineral density
Study 1: Silica supplementation in ovariectomised rats (animal model of postmenopausal osteoporosis) reduced bone resorption (bone breakdown) and increased bone formation (Calcif Tissue Int. 1993 Sep;53(3):174-9). A high concentration of silica was found in the areas of active bone mineralisation, where silica has combined with calcium in the bone-building cell.
Study 2: In a well-known massive-scale Framingham Offspring Study, the dietary habits of 2,847 participants (1,251 men & 1,596 pre- and postmenopausal women) aged between the ages 30 and 87 were studied since 1970, their bone density was also measured. The results showed the group which consumed more than 40mg of silicon per day had approximately 10% more bone density compared to the group which consumed less than 14mg of silicon daily. Hence, adequate silicon intake correlated positively with bone density in men and premenopausal women, but not in postmenopausal women. This study also suggested that the amount of dietary silica intake imposes a greater impact on bone density than the disparity in the amount of dietary calcium.
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Important notes! Regular silica does not improve bone density of postmenopausal women, but possible with Silica-Rx99! Oral administration of Silica-Rx99 was proven to increase bone density, even in those of postmenopausal women. The efficacy of Silica-Rx99 is far superior to regular silica. |
Study 3: 8 women aged between 45 and 82 years old and one man aged 58 years old were administered Silica-Rx99 (≥ 40mg silicon) daily for 6 months and their bone density were monitored. Amazingly, all 9 participants showed an increase in bone density (100% efficacy). On average, the bone density increased 13%, including those of postmenopausal women. Notably, Silica-Rx99 worked 4 to 6 times faster than a specific calcium supplement for all 9 participants. In this test, one participant who suffered from osteoporosis was experiencing decreasing bone density despite being prescribed drugs for osteoporosis. The test results indicated an unexpected increase in bone density after intake Silica-Rx99 for 6 months. Besides Silica-Rx99, no other silica products is capable of delivering such dramatic improvement in bone density within such short period of time yet. These significant findings have been published in Nippon Dental Newspaper and Medical Magazine Apolonia.
Study 4: Vitamin K2 suppresses the synthesis of prostaglandin E2 (PGE-2), a potent stimulator of bone resorption (bone broken down by the body). In this study, TNFα pro-inflammatory cytokine was used to induce PGE-2 production. The co-administration of Vitamin K2 (MK-7) and TNFα was effective in suppressing the PGE-2 production to a level comparable to baseline (control).
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b) Support bone elasticity (flexibility)
Animal studies in the 1970’s reported that deficiency of dietary silicon resulted in decreased bone tensile strength (Nature. 1972 Oct 6;239(5371):333-4; Science. 1972 Nov 10;178(4061):619-21). Another study showed that silica-deficient chicks were found to contain less collagen in their bones than those of silica-supplemented chicks (Calcif Tissue Int. 1981;33(1):27-34).
c) Support strong bone
Study 1: A study conducted on elderly women reported that non-osteoporotic women have particularly high vitamin K2 (MK-7). This suggests the association between high MK-7 and strong bones.
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Study 2: A study showed that vitamin K2 (MK-7) is more effective than vitamin K1 in increasing activity of osteocalcin, a vitamin K-dependent calcium-binding protein in bone that has been linked to bone formation.
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Study 3: In a double-blind, randomised clinical trial, 244 healthy postmenopausal women (55 to 65 years old) were orally administered 180 µg vitamin K2 (MK-7) daily for 3 years. The results showed that vitamin K2 (MK-7) significantly improved bone strength and protected the vertebrae and the hip against osteoporosis and bone fracture (Vermeer C. et al. 2012. VitaFoods).
d) Reduce risk of bone fracture
A meta-analysis concluded that vitamin K2 plays a vital role in the maintenance and improvement of bone mineral density and the prevention of fractures in postmenopausal women with osteoporosis (Osteoporos Int. 2015. 26(3): 1175-1186). High vitamin K2 has been associated with reduced vertebral (spinal) fractures by 60%, hip fractures by 77% and all non-vertebral fractures by 81% (Arch Intern Med. 2006. 166(12): 1256-1261).
Joint & muscle health
a) Relieve joint discomforts & inflammation
A study showed that administration of silica-containing supplement to patients with mild to moderate knee osteoarthritis provided relief for osteoarthritis symptoms and improved joint function within one to two weeks of treatment (J Inflamm (Lond). 2005. 2: 11). Besides, silica supplementation also helped enhance rate and quality of recovery from tendon and ligament damage (Front Aging Neurosci. 2016. 8: 202).
Cardiovascular health
a) Support healthy blood pressure:
Study 1: In an animal test, spontaneously hypertensive subjects were orally administered silica for 8 weeks and they showed significantly lower systolic blood pressure compared to animals administered with a control diet (Nutr Res. 2011. 31(2): 147-156).
Study 2: In an in vitro study, silica increased magnesium uptake by aortic smooth muscle cells by 177%, compared to cell culture without addition of silica (Nutr Res. 2011. 31(2): 147-156). Magnesium uptake helps relax the smooth muscles in blood vessels, allowing them to dilate and accommodate efficient blood flow.
Study 3: A study found that people taking 368mg magnesium supplements daily for 3 months helped lower both systolic and diastolic blood pressure (Hypertension. 2016. 68: 324-333).
b) Support healthy inflammatory response:
Silica suppressed production of aortic cells’ angiotension (a hormone that increases blood pressure) and growth factors related to inflammation, which could negatively affect blood vessel walls and impedes blood flow. Silica also stimulates the production of PPAR-ɣ, which has anti-inflammatory and blood pressure-lowering effects (Nutr Res. 2011. 31(2): 147-156).
c) Support healthy blood lipids
Studies suggested that silica regulates blood lipids and reduces the risk of arterial plaque (Life Sci. 1988. 42(21): 2105-2112), as well as decreases the likelihood of thickening, stiffening and narrowing of blood vessels (Med Hypotheses. 1997. 49(2): 175-176).
d) Reduce arterial calcification
Low dietary vitamin K can lead to uncontrolled mineralisation of calcium in arterial walls (arterial calcification), which has been shown to contribute to cardiovascular diseases (CVDs).
Study 1: A 10-year population-based study that included 4807 men and women aged 55 or older showed that >32 µg vitamin K2 intake per day was associated with ~50% reduction of aorta (largest artery) calcification, ~50% reduction of cardiovascular mortality (death) and ~25% reduction of all-cause mortality (death), compared to <21µg/day of vitamin K2 intake. This study suggests that dietary vitamin K2 has a protective effect against coronary heart disease (CHD) in older men and women.
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Study 2: A study of 564 healthy Dutch postmenopausal women who participated in the Predictors of Response to Cardiac Resynchronization Therapy study (PROSPECT) showed that higher dietary intake of vitamin K2 (but not K1) was associated with a reduced risk of coronary artery calcification (Atherosclerosis. 2009. 203:489–493), which is the build-up of calcium in the arteries, causing blood vessels to narrow and leading to the development of heart disease.
e) Protect against cardiovascular ageing
In a double-blind, randomised clinical trial, 244 healthy postmenopausal women (aged 55 to 65) was orally administered 180 µg vitamin K2 (MK-7) daily for 3 years. Compared to placebo, MK-7 supplementation significantly prevented age-related stiffening of arteries (which is often due to arterial calcification) as evaluated by pulse wave velocity (PWV), suggesting that MK-7 could protect against age-related cardiovascular deterioration (Vermeer C. et al. 2012. VitaFoods).
f) Reduce risk of cardiovascular diseases (CVDs)
Study 1: This study involved 16,057 perimenopausal and postmenopausal women (49 to 70 years old) who are free of cardiovascular disease at the baseline. This studied population had an average intake of 211.7 µg vitamin K1 and 29.1 µg vitamin K2 per day, respectively. The 10-year follow-up study showed a 9% drop in the risk of developing coronary heart disease per each 10 µg of vitamin K2 intake, particularly menaquinone‑7 (MK-7). On the other hand, the dietary intake of vitamin K1 was not significantly associated with a reduced risk of cardiovascular disease (Nutr Metab Cardiovasc Dis. 2009. 19 (7): 504-510).
Digestive health
a) Help manage digestive problems
In a clinical trial, silica supplementation for 6 weeks resulted in decreased total upper and lower abdominal symptoms or discomforts, which included reflux, dysmotility (gut does not work properly at moving its contents), diarrhoea, constipation and irritable bowel syndrome (IBS) (Gastroenterol Res Pract. 2012. 2012: 750750). Furthermore, decrease in the duration of diarrhea, abdominal pain, distension, nausea and vomiting had been reported in other studies.
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Detoxification
a) Reduce aluminium levels in the body
A study conducted on a population of 65 years or older, which was followed for 15 years, showed that cognitive decline was greater in subjects with higher daily intake of aluminium from drinking water. On the contrary, an increase of 10mg/day in silica intake was linked to a reduced risk of dementia (Am J Epidemiol. 2009. 169(4): 489-496).
Brain Health
a) Reduce risk of dementia
A study found that women who developed Alzheimer’s disease had lower intake of silica. It can be concluded that intake of silica may have reduced the risk of developing Alzheimer’s disease in elderly women (Am J Clin Nutr. 2005. 81(4): 897-902).
Skin health
a) Support skin healthy & protect against UV-induced skin damage
A clinical trial showed that oral and topical use of silica resulted in significant improvements in skin elasticity, texture and hydration, as well as reduced signs of photoageing (premature ageing of the skin caused by repeated exposure to UV) (An Bras Dermatol. 2016. 91(3): 331–335). Another study reported improvements in skin moisture retention and skin smoothness after treatment with a supplement containing silica for 180 days (J Clin Aesthet Dermatol. 2012. 5(11): 28–34). Furthermore, a study conducted on women with sun-damaged skin showed that those who take 10mg silica daily for 20 weeks observed reduced wrinkles and decreased skin roughness (Arch Dermatol Res. 2005. 297(4): 147-153).
Hair health
a) Promote hair growth and support shiny hair
In a randomised, double-blind, placebo-controlled study, healthy women (21 to 75 years old) with thinning hair were orally administered a supplement containing silica or placebo daily for 180 days. The silica-treated group showed an increase in the number of terminal vellus hair at 90th and 180th day after treatment; while placebo-treated group showed a decrease. In addition, significantly more silica-treated subjects noticed improvements in overall hair volume, scalp coverage and thickness of hair after 90 days and improvement in hair shine after 180 days.
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Silica promoted hair growth
Case study 1: A visible increase in hair growth after consuming silica supplement for 90 and 180 days
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Case study 2: A visible increase in hair growth after consuming silica supplement for 90 and 180 days
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b) Support strong hair
In a randomised, double-blind and placebo-controlled study, 48 volunteers with thin hair were orally administered with 10 mg of silicon or placebo daily for a period of 9 months. Those administered with silicon showed a positive effect on hair tensile strength, including hair elasticity and strand resistance to breaking, as well as an increased area of the strand front section (cross sectional area), resulting in thicker hair (Arch Dermatol Res. 2007. 299: 499-505).
Nail health
a) Support healthy and strong nails
Study 1: A study showed that 10mg of silica daily for 20 weeks resulted in stronger and less brittle hair and nails (Arch Dermatol Res. 2005. 297(4): 147-153).
Study 2: A case study showed that supplementation of Silica-Rx99 significantly improved nail quality after 6 months of intake.
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CASE STUDIES:
Case study 1:
- Woman 75 years old
Oral administration: Silica-Rx99 (66 mg silicon daily) for 6 months
Results:
- Lumbar bone density increased by 2%
- Left femoral bone density increased by 2%
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Case study 2:
Subject: Mr. Matsuoka (75 years old)
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Case study 3:
Subject: Ms. Iida (75 years old)
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Case study 4:
Subject: Man 29 years old
Oral administration: Silica-Rx99 for 6 months
Results: Bone density and strength increased after 6 months
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#A T-score shows how much higher or lower the bone density of participant is compared to a healthy 30-year old adult. *A Z-score compares bone density of participant to the average bone density of people similar to the participant’s age and gender. For example, if the participant is a 60-year-old female, a Z-score compares her bone density to the average bone density of 60-year-old females. |
Case study 5:
Subject: Women in their 30s
Oral administration: Silica-Rx99 for 8 months
Results: Bone density increased remarkably after 8 months
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Watsons H.W.B (Health.Wellness.Beauty) Awards Winner
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Unity Popular Choice and Award Winner 2021
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Research proven to be 18.5x more effective than calcium in increasing bone density, Bioactive Silica also boosts the body’s own collagen production to build stronger, more flexible bones, as well as promotes healthy skin, hair, and nails.
1. Protects
Liposomes protect the nutrients from being broken down by digestive juice, allowing the nutrients to reach the intestines intact and absorbed into the bloodstream.
2. Encapsulates
Liposomes have a spherical-shaped hollow structure which encapsulates the vitamin D nutrient.
3. Delivers
Due to its similar structure to the cell membrane, the liposome fuses with the cell membrane, releasing the encapsulated vitamin D into the cell.
