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Before Symptoms Appear!
A study shows that the accumulation of Aβ protein (amyloid plaque) in brain, started as early as 20 years before the appearance of symptoms of brain deterioration.
The causes of brain deterioration are still unidentified but research suggests they probably include a combination of genetic, environmental and lifestyle factors (e.g. brain fatigue). In fact, two abnormal structures, namely amyloid plaques and neurofibrillary tangles (deposits of tau proteins) in the brain are prime suspects of nerve cells damage that could possibly lead to brain deterioration.
What are amyloid plaques?
Like dental plaques that form on teeth, amyloid plaques are clusters of Aβ protein deposits in the brain. In a healthy brain, the proteins would be broken down and removed from the brain naturally. However, in a deteriorating brain, the body is unable to remove these protein fragments and they accumulate to form hard and insoluble plaques between the neurons in the brain. This causes disruption to neurons communication and induces oxidative stress that affects the proper functioning of the brain.
What are neurofibrillary tangles?
Brain cells depend on an internal transport system to carry nutrients and other essential compunds throughout the extensive neural network. This system requires the normal structure protein called tau. In brain deterioration, threads of tau protein twist into abnormal tangles inside brain cells, leading to failure of the transport system and causing death of brain cells.
Brain deterioration may also be attributed to brain fatigue. Recent studies in Japan found that one of the possible root causes of brain deterioration is “Stress-induced Brain Fatigue”. Excessive stress coupled with unhealthy lifestyle and diets, environment contaminants and lack of sleep, produce free radicals, thereby causing the nerve cells to oxidise and the brain to fall into a state of fatigue. This may lead to symptoms of brain deterioration over a prolonged period.
Plasmalogens are a type of phospholipid present in almost all tissues of human, and are most abundant in the brain. They are essential for their critical role in memory, focus and other cognitive functions. Plasmalogen levels in the body begin to increase from foetal stage, peak by the 30s and start to decline thereafter. Research indicated that this decline affects brain performance, especially in plasmalogen-deficient seniors.
Breakthrough in Plasmalogen Research
The strong correlation between plasmalogens and brain deterioration had already been confirmed decades ago. However, these studies had made very little progress. The main reason for the slow progression was due to extraordinary amount of time and money required for plasmalogen extraction and detection. In addition, there was no high-volume extraction technology available to extract large amount of plasmalogen for animal testing and clinical trial. However, a research team led by Emeritus Professor, Takehiko Fujino of Kyushu University in Japan has successfully established a simple plasmalogen detection method and developed a patented plasmalogen extraction method to extract large volumes of high purity (92%) plasmalogens. These discoveries have led to a major breakthrough in plasmalogen research.
Studies have also shown that plasmalogen levels are significantly reduced in the brain tissue and serum of patients with brain deterioration. The decline of plasmalogen is associated with the severity of cognitive impairment.
Plasmalogens are available from many sources of food. However, studies have proven that the structure of Scallop-derived PLASMALOGEN is closest to that of the plasmalogens found in the human body. In addition,plasmalogen from scallop is found to have better and quicker effects than chicken-derived plasmalogens in the improvement of cognitive function.
A promising approach towards healthy brain function
Intensive clinical studies by researchers in Japan have confirmed positive results of Scallop-derived PLASMALOGENS in supporting cognitive functions of patients with brain deterioration! This amazing discovery brings a new hope to the patients and their loved ones.
Subject C: 80-year-old male, brain deteriorationfor 3 years
Although the symptom of repeating activities continues, he began to actively enjoy life after consuming Scallop-derived PLASMALOGEN for 3 months. He took part in ball games at the elderly club, invited friends for a meal and grew vegetables in the garden. His MMSE score also improved by 5 points in 3 months.
Subject D: 70-year-old female, brain deterioration for 11 years
She suffered from severe delusion and could not take care of herself. Changes were seen two months after she consumed scallop-derived PLASMALOGEN. She was able to apply lipstick and put on accessories without any help. This reduced the burden on her husband as her caregiver.
Subject E: 70-year-old male, brain deterioration for 1 year
He became irritable due to his inability to carry out his daily tasks. His skill in “Go” (Chinese board game) slackened from level 6 to the beginner’s level. Changes were observed after he consumed Scallop-derived PLASMALOGEN. He became more cheerful and empathetic. He recovered and his skill in “Go” was reinstated to level 6. Now he volunteers and teaches “Go” at a day service facility.
Superior Qualities of NeuroREGAIN
NeuroREGAIN is highly recommended for:
1. N. Engl. J. Med. 367(9): 795-804 (2012)
2. Biochimica et Biophysica Acta. 1822: 1442-1452 (2012)
3. J. Lipid Res. 48: 2485-2498 (2007)
4. J. Neuropathol. Exp. Neurol. 58: 740-747 (1999)
5. Ann. N.Y. Acad. Sci. 1262: 85-92 (2012)
6. EBioMedicine 17: 199-205 (2017)
Contents: 230mg x 60 vegecaps (2 vegecaps = 1 mg Scallop-derived PLASMALOGEN)
NeuroREGAIN is available selected Watsons and at the following Unity Pharmacies: