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Recommended Dosage:
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Cases |
Daily dosage |
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General brain health maintenance
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1 capsule (0.5mg plasmalogen) |
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Individuals with poor cognitive function: forgetfulness, difficulty concentrating and poor mental clarity [診療と新薬 53: 12（2016） ] or family history of brain deterioration |
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Individuals diagnosed with brain deterioration [EBioMedicine 17: 199-205 (2017)]
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1 capsule in the morning; 1 capsule in the afternoon or night# (Total 1mg plasmalogen in a day)
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- Preferably taken on an empty stomach or 2 hours after meal.
- Dosage is optimised at 2 capsules a day (taken separately). Taking more is not recommended.
- If necessary, capsule may be opened and mixed with water for ease of consumption. Do not use hot water.
* Based on clinical studies, best results are achieved with 1 capsule (0.5mg), 2 times a day. Combining 2 capsules (1 mg) in one serving is not recommended.
Supporting evidence 1:
In a clinical trial, patients (aged 60 – 85 years) with mild brain deterioration were orally administered 0.5mg Scallop-derived PLASMALOGEN or placebo twice a day for 24 weeks and their cognitive functions were assessed. Oral administration of Scallop-derived PLASMALOGEN significantly improved memory function of the mild brain deterioration patients, in which significant memory improvement was also seen in a subgroup of female subjects and those who were younger than 77 years old. No clinically relevant adverse events were observed and thus, it is safe for consumption.
Taking 0.5mg Scallop-derived PLASMALOGEN twice a day significantly improved the cognitive function of
patients with mild brain deterioration
Mild brain deterioration patients
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Female mild brain deterioration patients
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EBioMedicine 17: 199-205 (2017)
Mild brain deterioration patients aged 77 or younger
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EBioMedicine 17: 199-205 (2017)
Supporting evidence 2:
According to another clinical trial, patients with mild and moderate brain deterioration who were given 0.5mg plasmalogen twice a day for 6 months observed the most significant improvement in cognitive function (as assessed by MMSE scores), compared to those on a higher dosage. A higher MMSE score indicates better cognitive function.
Taking 0.5mg Scallop-derived PLASMALOGEN twice a day resulted in the most remarkable improvement in cognitive function
of patients with mild and moderate brain deterioration
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Supporting evidence 3:
Another clinical trial conducted on individuals with poor cognitive function showed that oral administration of 0.5mg plasmalogen resulted in significant improvement of cognitive function (↑MMSE scores).
Taking 0.5mg plasmalogen daily improved cognitive function of those with mild cognitive impairment
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Supporting evidence 4:
In addition to clinical trials, feedback from customers also revealed that effects from taking 2 capsules (1mg plasmalogen) in one go was not as good as 1 capsule (0.5mg plasmalogen) twice daily.
The Clock Drawing Test
1) Have the person draw the face of a clock and put the numbers in the correct positions on a piece of paper.
2) Then have him/her draw the hands to indicate the time, such as 3:40 - one hand of the clock on 3 and the other on the 8.
3) Put a date for each Clock Drawing Test
Click here to download the guideline to learn how to assess the Clock Drawing Test.
Note: We would appreciate it if you could send us the Clock Drawing Test results to [email protected] Do share the results with others to help more people with brain deterioration, for which there is currently no medicines in the market that has a cure.
The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.
By using the Site, you agree that you have read and acknowledge the above and the Terms of Use for this Site.
Brain Deterioration Began 20 Years
Before Symptoms Appear!
A study shows that the accumulation of Aβ protein (amyloid plaque) in brain, started as early as 20 years before the appearance of symptoms of brain deterioration.
Causes of brain deterioration
The causes of brain deterioration are still unidentified but research suggests they probably include a combination of genetic, environmental and lifestyle factors (e.g. brain fatigue). In fact, two abnormal structures, namely amyloid plaques and neurofibrillary tangles (deposits of tau proteins) in the brain are prime suspects of nerve cells damage that could possibly lead to brain deterioration.
What are amyloid plaques?
Like dental plaques that form on teeth, amyloid plaques are clusters of Aβ protein deposits in the brain. In a healthy brain, the proteins would be broken down and removed from the brain naturally. However, in a deteriorating brain, the body is unable to remove these protein fragments and they accumulate to form hard and insoluble plaques between the neurons in the brain. This causes disruption to neurons communication and induces oxidative stress that affects the proper functioning of the brain.
What are neurofibrillary tangles?
Brain cells depend on an internal transport system to carry nutrients and other essential compunds throughout the extensive neural network. This system requires the normal structure protein called tau. In brain deterioration, threads of tau protein twist into abnormal tangles inside brain cells, leading to failure of the transport system and causing death of brain cells.
Brain Fatigue
Brain deterioration may also be attributed to brain fatigue. Recent studies in Japan found that one of the possible root causes of brain deterioration is “Stress-induced Brain Fatigue”. Excessive stress coupled with unhealthy lifestyle and diets, environment contaminants and lack of sleep, produce free radicals, thereby causing the nerve cells to oxidise and the brain to fall into a state of fatigue. This may lead to symptoms of brain deterioration over a prolonged period.
What are Plasmalogens?
Plasmalogens are a type of phospholipid present in almost all tissues of human, and are most abundant in the brain. They are essential for their critical role in memory, focus and other cognitive functions. Plasmalogen levels in the body begin to increase from foetal stage, peak by the 30s and start to decline thereafter. Research indicated that this decline affects brain performance, especially in plasmalogen-deficient seniors.
Breakthrough in Plasmalogen Research
The strong correlation between plasmalogens and brain deterioration had already been confirmed decades ago. However, these studies had made very little progress. The main reason for the slow progression was due to extraordinary amount of time and money required for plasmalogen extraction and detection. In addition, there was no high-volume extraction technology available to extract large amount of plasmalogen for animal testing and clinical trial. However, a research team led by Emeritus Professor, Takehiko Fujino of Kyushu University in Japan has successfully established a simple plasmalogen detection method and developed a patented plasmalogen extraction method to extract large volumes of high purity (92%) plasmalogens. These discoveries have led to a major breakthrough in plasmalogen research.
Plasmalogen and Brain Functions
Studies have also shown that plasmalogen levels are significantly reduced in the brain tissue and serum of patients with brain deterioration. The decline of plasmalogen is associated with the severity of cognitive impairment.
Clinical effectiveness of Scallop-derived PLASMALOGEN on patients with mild brain deterioration
In a clinical trial, patients (aged 60 – 85 years) with mild brain deterioration were orally administered 1,000 μg (500 μg twice a day) Scallop-derived PLASMALOGEN or placebo daily for 24 weeks and their cognitive function was assessed.
Oral administration of Scallop-derived PLASMALOGEN significantly improved memory function of the patients with mild brain deterioration in which significant memory improvement was also seen in a subgroup of female subjects and those who were younger than 77 years old. No clinically relevant adverse events were observed and thus, it is safe for consumption.
Scallop-derived PLASMALOGEN improves cognitive function of patients with mild brain deterioration
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EBioMedicine 17: 199-205 (2017)
Subject C: 80-year-old male, brain deterioration for 3 years
Although the symptom of repeating activities continues, he began to actively enjoy life after consuming Scallop-derived PLASMALOGEN for 3 months. He took part in ball games at the elderly club, invited friends for a meal and grew vegetables in the garden. His MMSE score also improved by 5 points in 3 months.
Subject D: 70-year-old female, brain deterioration for 11 years
She suffered from severe delusion and could not take care of herself. Changes were seen two months after she consumed scallop-derived PLASMALOGEN. She was able to apply lipstick and put on accessories without any help. This reduced the burden on her husband as her caregiver.
Subject E: 70-year-old male, brain deterioration for 1 year
He became irritable due to his inability to carry out his daily tasks. His skill in “Go” (Chinese board game) slackened from level 6 to the beginner’s level. Changes were observed after he consumed Scallop-derived PLASMALOGEN. He became more cheerful and empathetic. He recovered and his skill in “Go” was reinstated to level 6. Now he volunteers and teaches “Go” at a day service facility.
Choose your Plasmalogen wisely
Look for the one that is extracted from a natural source (to be safe) and clinically proven (to be effective).
i) Comparison to plasmalogen precursor (drug):
| Comparison | NeuroREGAIN (Supplement) | Plasmalogen precursor (drug) |
| Nature |
Natural plasmalogen |
Synthetic plasmalogen precursor |
| Conversion |
No conversion is needed:
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May involve multiple conversion steps2:
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| Functional dosage | Yes, proven by clinical research (1mg/day) | Unknown, no data available |
| Efficacy proven by clinical trials? |
Yes, promising data 1. Increases plasmalogen levels in cells
2. Improves cognitive function (memory)
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Unknown, no data available 1. No data available 2. No data available |
ii) Comparison to other plasmalogen supplement:
| Comparison | NeuroREGAIN | Brand X |
| Natural Source |
Scallop1 |
Unknown |
| Functional dosage? |
Yes (1mg/day) Research shows that 1mg/day is the optimal dosage. Dosage higher than 1mg/day will result in lower potency and hence, is not recommended. |
Unknown (14mg/day) |
| Efficacy proven by clinical trials? |
Yes, promising data 1. Increases plasmalogen levels in cells
2. Improves cognitive function (memory)
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Unknown, no data available
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Contains curcumin to help breakdown of amyloid plaque build-up? |
X
Plasmalogen is research proven to suppress amyloid plaque build-up. Co-administration with curcumin is unnecessary.
Green area: amyloid β proteins which could accumulate to form plaque. |
√ No data to support absorption & bioavailability of curcumin |
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Endorsement and feedback |
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| Cost | Lower | Higher |
1. Scientific studies have shown that scallop is a better source of plasmalogen than chicken for the following reasons:
- The structure of plasmalogen extracted from scallop is closer to those found in the human body.
- Plasmalogen from scallop is enriched with higher amount of omega-3s (DHA and EPA), thereby giving it the added efficacy of serving the functions of both plasmalogen and the two essential omega-3s.
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Comparison
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Scallop Plasmalogen |
Chicken Plasmalogen
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EPA |
23.9% |
- |
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DHA |
38.9% |
18.6% |
- Clinical trials have shown that plasmalogen extracted from scallop has quicker effect on the improvement of cognitive function than plasmalogen extracted from chicken.
Unity Popular Choice and Award Winner
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These specific clinical trials (human studies) are conducted with NeuroREGAIN. As such, these clinical trials video footages are not applicable for any other scallop-derived plasmalogen supplements.
Beware of other plasmalogen supplements that repost these videos from LABO Nutrition and claim identical effectiveness.
NeuroREGAIN is the ONLY scallop-derived plasmalogen formula in the market with this specific mix of
1. 92% purity scallop-derived plasmalogens
2. Patented extraction technology
3. Divided dosage (2 capsules)
Plasmalogens are a type of phospholipid present in almost all human tissues, most abundantly in the brain. It declines after age 30 and research indicated that this decline affects memory, focus & brain performance. Scallop is a better source of plasmalogen for use by humans as its structure is closest to plasmalogens found in the human body thus far. Other plasmalogen sources include krill oil, cow & chicken breast and shark liver oil.
Extracted from Hokkaido Scallops
Scallop is the Ideal Source of Plasmalogen
Plasmalogen from scallop is found to have better and quicker effects than chicken-derived plasmalogens in the improvement of cognitive function.
NeuroREGAIN is a high potency brain health formula containing scallop-derived plasmalogens extracted using a unique patented extraction technology developed by a research team led by Emeritus Professor, Takehiko Fujino of Kyushu University in Japan.
With clinically proven brain health benefits, NeuroREGAIN is natural, highly safe, pure, free of heavy metals and preservatives. It is not a drug with no prescription required.
Alzheimer's Morris Water Maze
Progress of cognitive functioning shown in the Clock Drawing test done by Tom Yip, a cancer survivor with dementia after taking scallop-derived plasmalogens (NeuroREGAIN).
Subject became more expressive and responsive after taking scallop-derived plasmalogens (NeuroREGAIN) for 2 weeks.
Subject’s MMSE score improved from 18 (moderate dementia) to 23 (mild dementia).
Mr Tom Yip (75 years old) is a cancer survivor with brain deterioration whilst also suffering from hallucinations. His condition showed no progress after taking prescribed drugs. He also tried taking coconut oil in which he observed improvement initially, but the condition later worsened.
He tried scallop-derived plasmalogens while continuing his medication and coconut oil. After just 1 month, we see great improvement in his cognitive function through the Clock Drawing Test (CDT). CDT is widely used as a clinical screeining tool for cognitive impairment. Tom’s wife also noticed that he does not wake up during the wee hours of the morning as frequently as before.
From this, we can conclude that scallop-derived plasmalogen dietary supplementation will not interfere with existing medications and other supplements.
Madam Seki (83 years old) has poor memory and degenerating brain function. Initially, she has little facial expression and could not hold a conversation. However, after taking scallop-derived plasmalogens for just 1 week, her family members are amazed to see that she looked more expressive, just like how she was before her diagnosis. Neighbors also observed that she looked more cheerful
Mr Lai (86 years old) needed a caregiver because he has difficulty controlling his shaky hands and cannot feed himself. He also experienced hallucinations and often “sees” people entering and leaving his high-rise apartment through the window. He started taking scallop-derived plasmalogens in September 2016, 1 veggie cap in the morning and 1 in the evening. By December 2016, the hallucinations have disappeared and he is able to feed himself. He is delighted to resume some of his favorite past times activities like playing mahjong and occasional horse-betting. Mr Lai’s improvement was so great that even his doctor was amazed.
My 46 year old husband has had memory problems since his early 40s. He was always unfocused in his daily activity and cannot remember if he has even eaten. It was not like this in his younger days. As he struggled with memory loss, he became very frustrated and depressed; it also affected his work performance. Besides having to deal with forgetfulness, Jack also suffered from severe insomnia as he could not calm his mind in the nights.
I was very worried that his condition was deteriorating and felt helpless. A friend introduced us to NeuroREGAIN, hoping it would help Jack. After taking 1 capsule daily for 1 month, Jack’s memory has improved. He is more aware of his surroundings and his mind is clearer too. Jack’s memory, temperament and sleep quality has gotten better with NeuroREGAIN.
When I first purchased NeuroREGAIN 6 months ago, my 90 year old father was in the severe stage of brain deterioration. In the time after, his condition did not change and even seemed to worsen.
But only 2 weeks ago, I started noticing an improvement. My father used to stay silent the whole day, but he is now talking more, even though not every word is clearly articulated. He also looks for the bathroom and refuses to pee into the portable urinal he used to use. My father also asks to take a walk instead of using the wheelchair like before.
It is very hard to explain, but we see him “re-learning” his life and also “reconnect” to his old memories. We don’t know if there will be further improvement, but we only wish for him to have a good and peaceful life. We are very happy with his progress and hope that our father’s story can help and encourage those suffering from brain deterioration and their family members.
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