FlexC MAX EX

Active ingredients per 2 capsules: 100mg Boswellin® Super Boswellia serrata Extract, 400mg Curcumin C3 Reduct® Turmeric Root Extract, 10mg BioPerine® Black Pepper Extract, 140mg Devil’s Claw Extract 

Unique properties of key ingredients

Boswellin® Super Boswellia Extract:

• Standardised to 30% AKBA
• Research proven safety and efficacy
• Kosher and Halal certified
• Patented in US, Europe and globally, pertaining to specific applications of boswellic acids

Curcumin C3 Reduct®

• Derived from Curcumin C3 Complex®
• Standardised to 95% Tetrahydrocurcuminoids, which is the colourless hydrogenated product derived from the curcuminoids (primarily curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)), which is extracted from the rhizomes of Curcuma longa.
• Highly safe. The safety of oral administration of THC has been established in humans.

THC is highly safe

In the clinical trial, 300mg of THC was administered to 20 healthy human volunteers once daily for 28 days and 15 vital parameters were evaluated. Results showed that THC was safe for oral administration:

• High absorption and bioavailability : THC is more easily absorbed in the intestines compared to curcumin.

THC is more easily absorbed in the intestines than curcumin

In this experiment, one group of mice was fed with a diet containing 0.5% curcumin, while the other group was fed with a diet containing 0.5% THC for 1 month. At the end of the study, concentration of THC was higher than curcumin in liver and blood serum in both groups. Hence, it can be concluded that orally administered THC can be absorbed more easily in the intestines compared to curcumin.  

• Superior stability: THC is more stable than curcumin in physiolocal pH.
• High efficacy : It is not the curcumin, but THC (converted from curcumin) that is responsible for biological functions in the body.
• Approved by authority in Canada: Curcumin C3 Reduct® has received approval from NNHPD (Natural and Non--prescription Health Product Directorate), the regulatory authority in Canada.
• High credibility: Kosher and Halal certified, GMO-free, TSE-BSE-free, Nanotechnology-free, ISO 22000:2005, FSSC 22000:2011, NSF GMP, FDA-Audited, FSSAI
• Award-winning: Awarded 2014 Functional Ingredients Editor’s Choice Award for Best Science (Curcumin C3 Reduct® overcome absorption barrier that regular curcumin must go through) 
• Patents No. US6653327, AU2006235807, EP1171144, EP1328263, NZ514884

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BioPerine® Black Pepper Extract:

• Standardised to ≥ 95% piperine
• Highly safe. Granted GRAS status after a comprehensive review of safety and toxicology data by an independent panel of scientists with international repute.
• Research proven safety and efficacy
• Long-standing ingredient. Introduced in the marketplace since 2 decades ago to enhance bioavailability of other nutrients
• Kosher and Halal certified
• Patented in US, Europe, Japan and Canada

Devil’s Claw Extract:

• Standardised to 2.5% Harpagoside

Take 1 capsule after meal, 2 times daily.

The bioavailability of various boswellic acids, especially AKBA was shown to be significantly enhanced by concomitant administration of a fat-containing meal (e.g. fried eggs, bacon, milk etc.)

Caution: Dietary supplements are not a substitute for a healthy diet. If you are pregnant, nursing or taking any medication, please consult your physician before consuming any supplements. Discontinue use 2 weeks before surgery.

Storage: Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
This product is not intended to diagnose, treat, cure or prevent any disease.

Research-proven Health Benefits of Key Ingredients

The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.

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1) Support healthy inflammatory response in joints

Study 1: Human leukocyte elastase (HLE) is known to trigger inflammation and pain within the joints. It has been suggested to attribute to rheumatoid arthritis due to its aggressive and destructive properties. In this in vitro study, boswellic acid AKBA was found to significantly inhibit HLE, thereby reducing joint inflammation and pain.

Study 2: In an in vitro study, Boswellia serrata extract was found to significantly reduced and normalised the production of pro-inflammatory factors - nuclear transcription factor κB (NF- κB), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cartilage cells.

 Study 3: NF-ĸB is the master regulator of inflammation and plays a role in a wide variety of pathological conditions. In an in vitro study, cells were pre-incubated with curcumin for 60 minutes followed by PMA or H₂O₂ for 30 minutes and then tested for NF-ĸB activation. Curcumin was found to completely block PMA and H₂O₂-induced activation of NF-ĸB, indicating curcumin is a general suppressor of NF-ĸB activation.

Study 4: Interleukin (IL)-6 (IL6) and prostaglandin E₂ (PGE₂) promote inflammation and play a role in the development of rheumatoid arthritis (RA). In an in vitro study, anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated synovial cells derived from patients with rheumatoid arthritis (RA). Piperine was shown to suppress the production of IL-6 and PGE₂ in a dose-dependent manner. 

2) Reduce joint and low back pain

Study 1: In this clinical trial, patients with hip and / or knee osteoarthritis were orally administered devil’s claw (Harpagophytum procumbens) or diacerhein (slow-acting drug for osteoarthritis) for 4 months. After 4 months, both groups showed considerable improvements in osteoarthritis symptoms, with no significant differences for pain, functional disability, or the Lequesne score, which is a questionnaire to assess the severity of osteoarthritis. Additionally, group administered with devil’s claw showed significant reduction in the use of analgesic and nonsteroidal anti-inflammatory (diclofenac) medications. These findings suggest the efficacy of devil’s claw in relieving the symptoms of osteoarthritis, which helps reduce the need for painkiller (Joint Bone Spine. 2000; 67(5): 462-467).

Study 2: In this clinical trial, patients with chronic back problems seeking treatment for acute attacks of pain were orally administered devil’s claw (Harpagophytum procumbens) or placebo for 4 weeks. After 4 weeks, 17.6% of patients administered with devil’s claw were pain-free, while only 1.9% patients in placebo were pain-free. Besides, the percentage change in Arhus index for improvement in pain was greater in those who were administered with devil’s claw, compared to placebo. These findings suggest the efficacy of devil’s claw in reducing low back pain (Phytomedicine. 1996 May; 3(1): 1-10).

Study 3: Boswellia serrata extract (50mg/kg) was administered to subjects for 21 days after the induction of arthritis (joint inflammation). When compared to control, Boswellia-treated group was found to be significantly decreased in edema (swelling) volume (p < 0.01). The study concluded that Boswellia serrata could be an effective adjuvant for arthritis management.

Study 4: Subjects with paw pain and arthritic ankle were orally administered piperine at 20 and 100 mg/kg/day for 8 days which resulted in significantly reduced pain and arthritic symptoms. Furthermore,  piperine was also shown to significantly reduce the inflammatory area in the ankle joints. These results suggest that piperine could suppress inflammation and pain for those with joint problems.

3) Protect healthy joint structures

Patients with rheumatoid arthritis (RA) who experienced joint pain showed higher levels of serum hyaluronic acid¹, suggesting an outflow from cartilaginous tissue. In this study, healthy adults with knee pain who consumed 100 mg/day of Boswellin® Super for 8 weeks showed lower levels of serum hyaluronic acid than those in the placebo group. This suggests the potential use of Boswellin® Super in protecting cartilage and alleviating pain in rheumatoid arthritis.

4) Synergistic benefits of combined ingredients

a) Curcumin and Boswellia extract

Study 1: In a randomised, double-blind, placebo-controlled trial, 201 patients with osteoarthritis (OA) were orally administered placebo, curcumin (Curcuma longa) or its combination with boswellic acid (Boswellia serrata) daily for 12 weeks and their conditions were evaluated at baseline and week 12. Both preparations resulted in a reduction of pain-related symptoms, but a combination of curcumin and boswellic acid was more effective, presumably due to synergistic effects of curcumin and boswellic acid.

Study 2: A combination of turmeric and boswellia extracts were also shown to be more effective in reducing pain than NSAID, which is a drug commonly prescribed for joint disorders. 

In a clinical trial, osteoarthritic patients (age 18 - 65 years) were orally administered a CB formulation consisted of 350mg Curcuma longa  (turmeric) extract (containing 70% curcumin, 17% demethoxycurcumin, 3.5% bisdemethoxycurcumin and 7.5% turmeric essential oils) and 150mg Boswellia serrata extract (containing 75% boswellic acids and 10% AKBA) in 500mg hard gelatin capsule twice daily or NSAID 100mg capsule twice daily for 12 weeks. The turmeric + Boswellia formulation was found to be more successful than NSAID for symptom scoring and clinical examination.

b) Curcumin and BioPerine®

Following oral administration, curcumin showed poor absorption resulting in low blood concentration (traces) and most of them are excreted in the faeces. However, several studies have shown that the presence of BioPerine® (an extract from black pepper fruits Piper nigrum) helped increase the bioavailability of Curcumin.

Study 1: In a test, curcumin concentration in blood serum was shown to increase significantly at 1 and 2 hours following administration of a combination of curcumin and BioPerine®.

Study 2: In a clinical trial, 10 healthy volunteers were first administered 2000 mg curcumin, followed by a two-week break before a second administration of 2000 mg of curcumin and BioPerine^® (20 mg) combination. BioPerine® was shown to enhance the bioavailability of curcumin with curcumin serum concentration increased by 20-fold or 2000% compared to curcumin alone. BioPerine® inhibits metabolism and elimination in intestine and liver and thus, increasing the bioavailability of curcumin.

5) Support Overall Body Wellness

a) Support healthy blood glucose

Tetrahydrocurcumin (THC) helps stimulate pancreatic β-cells, which play a vital role in the production and secretion of hormone that regulates blood glucose levels. Research showed that oral administration of THC (80 mg/kg body weight) to diabetic rats for 45 days resulted in a significant reduction in blood glucose and a significant increase in the hormone that regulates blood glucose levels, indicating the antidiabetic effect of THC.

b) Support healthy blood lipids

High blood lipid or hyperlipidemia is an associated complication of diabetes. In this study, oral administration of THC (80 mg/kg body weight) to diabetic rats for 45 days resulted in a significant reduction of serum and liver cholesterol, triglycerides, free fatty acids, phospholipids, HMG-CoA reductase activity, very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol levels and an increase of high-density lipoprotein (HDL). It is important to note that THC has more potent anti-hyperlipidemic effects, compared to the same dose of curcumin.

c) Support anti-ageing by anti-glycation

Glycation is a chemical process in which sugar, such as glucose is attached to human proteins or lipids, leading to the formation of high reactive Advanced Glycation End Products (AGEs) (proteins or lipids that become glycated). AGEs are a contributing factor in aging and in the development or worsening of many diseases, such as diabetes, atherosclerosis, kidney disease or Alzheimer’s disease etc.

In this study, THC reduced the extent of glycation and AGEs formation measured in tail tendon of diabetic rats, indicating its potential as an anti-glycation compound.

d) Protect liver health

Oral administration of THC significantly hindered the occurrence of liver damage as observed from reduction of levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin. These findings showed that THC could effectively protect against liver damage. Besides, THC provides a better protection when compared to reference drug Silymarin.