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Ingredients: Water, Dimethicone, Diglycerin, Diphenylsiloxy Phenyl Trimethicone, Menthyl Lactate, PEG-9 Polydimethysiloxyethyl Dimethicone, Glycerin, Magnesium Sulfate, Dimethicone/ PEG-10/15 Crosspolymer, Vanillyl Butyl Ether, Dimethicone/ Phenyl Vinyl Dimethicone Crosspolymer, Phenoxyethanol, Lauryl PEG-10 Tris(Trimethylsiloxy) Silylethyl Dimethicone, Cetyl PEG/PPG-10/1 Dimethicone, Methylparaben, Sodium Citrate, Mentha Arvensis (Hakka Yu), Sodium Benzoate, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Yeast 331 Strain(Saccharomyces Lysate Extract Filtrate containing S-adenosylmethionine)

How the bioactive peptides of FlexC CARE are developed
Using serial hydrolytic fermentation technology, bioactive proteins are produced and secreted in large quantities using high-performance food-grade microorganism. The proteins are then hydrolysed to yield Bioactive Peptides via site-directed hydrolysis process. This is followed by proprietary purification technology that isolates highly concentrated peptides. Since the molecules are small and can be absorbed easily, only a small amount of serum is needed to exert maximal efficacy.

Direction for use:
Gently massage a small amount onto clean, affected area, up to three times daily. Do not use on face.

Step 1: Ensure the right dosage required
The first time you use FlexC CARE EX serum, estimate the amount of serum you need to squeeze out of the bottle:
1. For a knee, shoulder or hip, squeeze a line as long as your index finger.
2. For an ankle, wrist or the fingers on one hand, squeeze a line as long as half of your index finger.

Evenly cover the soft tissue at the front and the back of the joint (do not apply to the knee cap)

It is important use the appropriate dose for the specific joint you are treating.
• You must allow the FlexC CARE EX serum to dry for at least 10 minutes, or until the skin is touch dry before covering the area.
• If the serum takes longer than 10 minutes to dry, you have probably applied too much. The excess can be wiped off and you should try using a smaller amount next time.
• If the serum takes less than 10 minutes to dry, you should apply slightly more the next time.


Step 2: Reduce the application time
Once you have worked out the right amount of FlexC CARE EX serum required for your specific joints, you can reduce the serum drying time by:
• Warming the skin before applying the serum
• After applying the serum, use a hairdryer on a medium setting to blow dry. This should reduce the drying time to about 2 minutes

For those who exercise: Apply a thin layer of serum to thigh and calf before exercise. Apply again after exercise. The aroma of fresh mint makes you feel more comfortable and soothing after exercise.

Caution: For external use only. Do not apply on open wounds or damaged skin. Discontinue use and seek advice from your physician if any adverse reactions such as allergic reaction or severe irritation arises. Avoid contact with eyes or other sensitive areas. Should the product get into eyes, rinse immediately with plenty of water.

If you are pregnant or nursing, please consult your physician prior to using this product.

Storage: Store in a cool, dry place at room temperature, away from heat, direct sunlight and moisture. Use within 3 months of opening. Keep out of reach of children.

Q. What is FlexC CARE EX?
A. FlexC CARE EX is a transdermal drug-free serum which is primarily made up of 2 proprietary Bioactive Peptides – Palmitoyl Tetrapeptide-7 and Palmitoyl Pentapeptide-4. Developed using proprietary fermentation and purification technology, the high purity and concentration peptides penetrate the skin and permeate into the target tissues for therapeutic and rejuvenating effects. These unique peptides help support healthy inflammatory response, repair and rebuild cartilage, tendons, ligaments and muscles that are strained or injured. This topical serum can easily be applied for the knees, hips, shoulders and heel region. Non-greasy and non-sticky, it is suitable for all types of skin.

Q. What makes FlexC CARE EX serum stand out from other joint creams?
A. FlexC CARE serum contains a high concentration of proprietary Bioactive Peptides. This is an anti-inflammatory agent which stimulates the production of extracellular matrix (ECM), aiding to repair, rebuild and nourish joint structures and muscles. The formula also contains Mentha Arvensis (Hakka Yu), a herb that is well-known for its natural pain relieving and anti-inflammatory properties. Penetrating deeper into the skin to reach the target tissues, FlexC CARE merges the best of science and nature to provide fast pain relief, long-lasting comfort and rejuvenating effects, so that you can get on with your day. Most users felt its soothing effects within hours of application. Recurrence is highly unlikely if FlexC CARE serum is continually applied as maintenance. Bioactive Peptides are unique and can hardly be found in other cream, gel or serum products available in the market.

Q. Why is FlexC CARE EX is not made for oral intake?
A. The primary active ingredients in FlexC CARE EX is peptides. If these peptides are taken orally, the protease enzymes in the gastrointestinal tract can degrade it before circulation is possible. This results in poor bioavailability and ultimately, only a very limited portion of peptides can reach the affected areas to exercise its beneficial effects. On the contrary, topical administration enables peptides to permeate the skin, directly reaching the affected joints and muscles, thereby eliciting local effects at the site of application, maximising the potency of FlexC CARE EX.

Q. Can I apply FlexC CARE EX serum while consuming joint supplements orally?
A. Yes, you are encouraged to do so. The unique Bioactive Peptides is only present in FlexC CARE and works as a perfect complement to oral joint supplements, such as FlexC MAX EX, FlexC PRO EX, Joint Sensei Supreme and SCP Cartilage Sensei Supreme. Each ingredient serves different purposes and their combined use offers a synergistic effect to restore optimal joint function, promoting a quicker recovery time.

Q. FlexC series has 3 products – FlexC CARE EX, FlexC MAX EX  and FlexC PRO EX. What is the difference?
A. FlexC CARE EX, FlexC MAX EX and FlexC PRO EX are intended to promote improved joint health. Refer to table below for comparison:

FlexC CARE EX  and FlexC MAX EX have a natural plant based formula, suitable for vegetarians who desire to improve their joint health. For non-vegetarians, FlexC MAX EX and FlexC PRO EX are great complement with FlexC CARE EX, working synergistically to deliver maximum benefits to joint structure, health and function.

Q. I have been suffering from chronic joint pain in the past one month, can I apply FlexC CARE EX serum?
A. Yes, you can. FlexC CARE EX helps reduce joint pain and support natural recovery of cartilage, tendons, ligaments and muscles. You may feel the relief within few hours of application. It is highly recommended to complement FlexC CARE EX with FlexC MAX EX, which is a vegetarian formula made up of patented herbal extracts and MSM which targets the root cause of joint discomfort. For non-vegetarians, FlexC CARE EX can also be complemented with FlexC PRO EX, which is an oral supplement comprising of proprietary collagen, MSM and calcium. This multi-functional formula helps support and strengthen body structure, including joints, muscles and bones.

Q. Can I use FlexC CARE EX serum for gout pain?
A. Yes, you can. Gout is a form of inflammatory joint problem that develops for people who have high uric acid in the blood. Without proper treatment, gout can cause chronic swelling and permanent joint damage. FlexC CARE EX serum is an ideal solution for those with gout problems as it has anti-inflammatory properties while still aiding to repair and rebuild joint structures. We recommend complementing FlexC CARE EX with AFC SCP Cartilage Sensei Supreme, which is also researched and proven to help reduce excessive uric acid in the blood.

Q. How soon can I feel pain relief after applying FlexC EX CARE?
A. When used as directed, most people feel relief within few hours after application. However, effect may vary between individuals, depending on severity of the pain and joint/muscle injury. For long-term joint comfort and repair, it is recommended to use FlexC CARE EX daily.


Q. How effective is FlexC CARE EX serum?
A. Several tests have shown that Bioactive Peptides in FlexC CARE EX helps support healthy inflammatory response and promote production of extracellular matrix, which is associated with joint tissue repair and regeneration.

Q. How should I apply FlexC CARE EX serum?
A. Gently massage a small amount onto affected area until fully absorbed. It is recommended to use FlexC CARE EX serum twice a day (once in the morning and once in the evening) for best results. Nonetheless, you can apply repeatedly during the day if you think there is a need. After shower, please allow 1 – 2 hours to pass before applying. As FlexC CARE EX serum has high concentration of active ingredients with superior potency, dispense an amount equivalent to the length of your index finger is sufficient for a knee, shoulder or hip. For the ankle, wrist or the fingers, dispense an amount equivalent to half the length of your index finger will be sufficient. Product should not be applied on the face.


Q. Are there any side effects associated with using FlexC CARE EX serum?
A. There are no serious side effects associated with the use of FlexC CARE EX serum. Whilst highly unlikely, FlexC CARE EX can cause skin irritations such as erythema (skin redness), dry skin or rash – intensity ranging between mild to moderate levels. These effects are transient and will fade naturally over time, thus not requiring further treatment. In the event of allergy reactions, serious irritation or other side effects, please discontinue use immediately and seek advice from your physician. FlexC CARE EX has no known interactions with medicines.

Q. Is it safe to use FlexC CARE EX serum during pregnancy or breastfeeding?
A. FlexC CARE EX has not been studied for use during pregnancy and breastfeeding. If you are pregnant or breastfeeding, we strongly advise you to consult your physician beforehand.

Q. Does FlexC CARE EX contain NSAIDs or synthetic painkiller?
A. No, it contains neither. FlexC CARE EX helps relieve pain via natural means with proprietary Bioactive Peptides and Mentha Arvensis (Hakka Yu) – both of which helps promote joint comfort and repair damaged joints. Thus, FlexC CARE EX is safe and recommended for long-term use.

Q. Can I use FlexC Care EX serum alongside with painkillers or other oral medicines?
A. Yes, you can. FlexC CARE EX is a drug-free serum and can safely be applied for those taking painkillers. Painkillers work by reducing inflammation but does not help repair joint structures. Hence, FlexC CARE EX serum is a good complement which aids to restore healthy joints quickly. Since FlexC CARE EX does not contain any pharmaceutical compounds, it will not interact with your oral medicine. Nonetheless, please consult a physician if you have any pre-existing health concerns.

Q. Can I use FlexC CARE EX for long-term?
A. Yes, you are advised to do so. Daily walking, moving, exercise or sports will eventually take a toll on the joints and muscles. Thus, joint repair and restoration should be an ongoing process. FlexC CARE EX serum helps speed up the process, preventing further damage to joints and muscles.

Q. Who can use FlexC CARE EX serum?
A. FlexC CARE EX is recommended to those suffering from joint discomfort, such as joint pain, stiffness, swelling or have limited range of motion. FlexC CARE EX is also suitable for anyone who has muscle pain, strain, cramps or is suffering from a sports injury. FlexC CARE EX helps regenerate cartilage and muscle loss from everyday wear and tear. It is particularly recommended for those who are physically active (jog, hike or participate in sports), middle-aged or elderly adults, individuals who are overweight or have a history of physical injuries. People with physically demanding jobs that require standing for long durations, wearing high heels daily or require repeated lifting and bending are at higher risk for joint injuries.

Q. Can I use body lotion after applying FlexC CARE EX serum?
A. Yes, you can. Please ensure that FlexC CARE EX serum is completely absorbed into the skin before applying your body lotion. Otherwise, body lotion may reduce the efficacy of FlexC CARE EX.


Research-proven Benefits of the Bioactive Peptides in FlexC CARE EX

The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.

By using the Site, you agree that you have read and acknowledge the above and the Terms of Use for this Site.

1) Support healthy inflammatory response

Swollen joint is one clinical feature of osteoarthritis (OA), attributed to local inflammation and thickening of synovium.

A membrane called the synovium produces a thick fluid that helps keep the cartilage healthy. The synovium can become inflamed and thickened when there is wear-and-tear on the cartilage. Inflammation causes more fluid to be produced within the joint, resulting in swelling and possibly the development of OA.

In this test, Bioactive Peptides were shown to suppress LPS-induced inflammatory response, as indicated by a reduced level of nitric oxide concentration (an inflammatory marker).

 2) Promote production of extracellular matrix (ECM) for repair and regeneration

The extracellular matrix (ECM) consists of collagen, fibronectin, hyaluronic acid and other components which play a vital role in tissue repair and regeneration.

a) Procollagen:
Procollagen is precursor of collagen synthesised by fibroblasts and other cells in the process of collagen synthesis. In this test, Bioactive Peptides had shown to increase synthesis of procollagen by human fibroblast.

b) Type I collagen:
Tendons and ligaments contain predominantly collagen, mostly type I to provide robust mechanical strength. Boosting collagen synthesis by fibroblast cells could potentially treat an injured tendon or ligament.

Bioactive Peptides were shown to increase type I collagen (stained brown in the diagram below) synthesis in tendon cells. The cells treated with Bioactive Peptides showed a deeper brown which indicate increased levels of type I collagen. 

c) Type II collagen:
Type II collagen is a major protein in joint cartilage, the smooth, white connective tissue that covers the ends of bones as they come together to form a joint. It is believed to contribute most to tensile behaviour of the cartilage tissue.

Bioactive Peptides were shown to promote synthesis of type II collagen in human cartilage cells. 

d) Fibronectin:
Fibronectin production appears to be an important part of cartilage, tendon, ligament and muscle healing process. In this test, Bioactive Peptides were shown to increase synthesis of fibronectin by human fibroblast. 

e) Extracellular matrix (ECM):
In this clinical trial, healthy human volunteers were treated with 50ppm of Bioactive Peptides for 60 days on their buttock skin. Biopsies were taken for immunohistochemical assessment of procollagen I, hyaluronic acid and fibronectin. After 60 days, tissue staining showed a significant increase in the amount of subcutaneous collagen, hyaluronic acid and fibronectin.

In conclusion, Bioactive Peptides stimulate the synthesis of procollagen, hyaluronic acid and fibronectin, collectively known as ECM in human body. 

3) Repair damaged joints
Connective tissues such as cartilage, tendons and ligaments in the joints are mostly composed of extracellular matrix (ECM). TGF-1 (a type of gene) is a well-known stimulator of ECM biosynthesis.
In this study, Bioactive Peptides were shown to synergise with TGF-1 to increase ECM biosynthesis.



• Painful, inflamed or stiff joints due to worn-out or injured cartilage, tendons or ligaments
• Sore shoulders and neck from sitting at the desk or using electronic devices over an extended period of time
• Painful spurs on the sole
• Muscle strain, aches & cramps and sprains
• Athletes, gym-goers or active individuals (e.g. jogging, running, hiking, cycling, playing basketball, martial arts etc.)
• Obese or overweight whose weight can put a burden on knee joints and increase risk of cartilage loss
• Physically demanding jobs (e.g. construction, agriculture, cleaning and retail sectors)
• Middle-aged or elderly
• Family history of joint disorders
• History of physical injuries or accidents which may increase the risk of future joint problems)
• Rotator cuff injury* (e.g. stiff shoulder)

*A rotator cuff injury is usually a strain or tear of the rotator cuff - the muscles, tendons and joint capsule that stabilises the shoulder. This injury can cause a dull ache on the shoulder and often worsen when one tries to sleep on the injured side.

FlexC CARE EX Transdermal Bioactive Peptide Serum is the ‘must-have’ joint and muscle care for active and pain-free mobility. Developed with proprietary Intrixyl® technology, FlexC CARE EX delivers highly concentrated Bioactive Type II Collagen Peptides and Yeast 331 Strain (S-adenosylmethionine) to deeply and rapidly penetrate into skin to reach the affected areas. This scientific breakthrough formula supports synthesis of extracellular matrix, protecting against cartilage loss and supporting healthy joint inflammatory response.

• Fast absorption & deep penetration – Nano bioactive peptides penetrate the skin and permeate to the targeted tissues to exert therapeutic and rejuvenating effects
• High concentration and efficacy – Peptides have to be of a certain concentration to effect any benefit. FlexC CARE EX’s bioactive peptides are highly concentrated, only a small dosage is sufficient to produce big effects.
• Quick, long-lasting relief – Soothes discomfort within hours of application
• High purity & safety – Bioactive Peptides are produced and purified with advanced technologies in Japan which passed SGS (safety & quality) test
• 100% free of steroids – Gentle on skin, can be applied multiple times a day. Suitable for all types of skin, including sensitive skins.
• Recognised by medical clinics around the world
• Non-greasy, non-sticky – Does not stain clothes, no sticky feeling after application

Nano Bioactive Type II Collagen Peptides are short chains of amino acids which send signals to targeted cells in the joints (e.g. cartilage cells, tendon cells) to stimulate the production of extracellular matrix (ECM) (e.g. collagen) and growth factor, both of which are important for the regeneration and repair of the joint tissues.

This scientific breakthrough formulation stimulates synthesis of extracellular matrix (ECM), including Type I & II collagens, fibronectin and growth factors, which are crucial for supporting healthy joint structures and muscles. In addition, the bioactive peptides of FlexC CARE EX also supports healthy inflammatory response and analgesic effects to support self-repair of the joints and muscles as well as support skin health by boosting skin vitality and metabolism.

The proprietary Intrixyl® Technology effectively encapsulates active ingredients, allowing them to penetrate deeply into the skin for the best effects. The flexible membrane can easily pass through the space between cells in the skin, providing the most efficient skin penetration to reach affected area in the deep tissue.

In serum form, it spreads easily and effectively. A small drop goes a long way. Our upgraded version of 50ml FlexC Care EX offer as much as 200 times usage.

Bioactive Peptides stimulate synthesis of type I and type II collagens, which are indispensable for healthy joints and connective tissues. Joint is alike to a house. In addition to cement (glucosamine), steel bars (type II collagen) of high strength and stability are required to support the house (joint) from collapsing.

1) Support healthy inflammatory response^
2) Repair damaged joints^

Produced using cutting-edge technology, Yeast 331 strain is a type of yeast that naturally contains a large amount of S-adenosylmethionine. S-adenosylmethionine is naturally present in the human body. When consumed orally, S-adenosylmethionine has been used to treat depression, liver diseases and osteoarthritis. Manufactured in Japan, this ingredient is also beneficial for joint health, especially the knee, by protecting against and improve locomotive syndrome and osteoarthritis.

S-adenosylmethionine exists in 2 forms which are SS and RS. S-adenosylmethionine in the Yeast 331 strain is in the same SS form that presents in the human body. Hence, it can be utilised effectively in the human body and exert better physiological effects.

After applying Yeast 331 Strain for 16 weeks, the inflammation (marked in orange) disappeared.

The cartilage thickness decreased remarkably for placebo group, which was administered non-steroidal anti-inflammatory drugs for 16 weeks. However, the cartilage thickness was maintained by the administration of Yeast 331 strain for 16 weeks. The result shows that Yeast 331 strain helps maintain cartilage health.

Direction of Use

Take FlexC PRO EX daily to strengthen and protect the joints. For fast relief and recovery, take FlexC MAX EX as well. And for specific pain areas, apply FlexC Care EX serum for targeted relief and direct absorption. For those who are above 40 years old, you can also take Bioactive Silica daily for bone strength and to boost the body’s own collagen production for stronger bones, hair, skin, nails and teeth.



Title FlexC CARE EX

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