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Active ingredients per 2 capsules: 100mg Boswellin® Super Boswellia serrata Extract, 400mg Curcumin C3 Reduct® Turmeric Root Extract, 10mg BioPerine® Black Pepper Extract, 790mg OptiMSM®.
Unique properties of key ingredients
Boswellin® Super Boswellia Extract:
- Standardised to 30% AKBA
- Research proven safety and efficacy
- Kosher and Halal certified
- Patented in US, Europe and globally, pertaining to specific applications of boswellic acids
Curcumin C3 Reduct®
- Derived from Curcumin C3 Complex®
- Standardised to 95% Tetrahydrocurcuminoids, which is the colourless hydrogenated product derived from the curcuminoids (primarily curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)), which is extracted from the rhizomes of Curcuma longa.
- Highly safe. The safety of oral administration of THC has been established in humans.
THC is highly safe
In the clinical trial, 300mg of THC was administered to 20 healthy human volunteers once daily for 28 days and 15 vital parameters were evaluated. Results showed that THC was safe for oral administration:
- High absorption and bioavailability : THC is more easily absorbed in the intestines compared to curcumin.
THC is more easily absorbed in the intestines than curcumin
In this experiment, one group of mice was fed with a diet containing 0.5% curcumin, while the other group was fed with a diet containing 0.5% THC for 1 month. At the end of the study, concentration of THC was higher than curcumin in liver and blood serum in both groups. Hence, it can be concluded that orally administered THC can be absorbed more easily in the intestines compared to curcumin.
- Superior stability: THC is more stable than curcumin in physiolocal pH.
- High efficacy : It is not the curcumin, but THC (converted from curcumin) that is responsible for biological functions in the body.
- Approved by authority in Canada: Curcumin C3 Reduct® has received approval from NNHPD (Natural and Non--prescription Health Product Directorate), the regulatory authority in Canada.
- High credibility: Kosher and Halal certified, GMO-free, TSE-BSE-free, Nanotechnology-free, ISO 22000:2005, FSSC 22000:2011, NSF GMP, FDA-Audited, FSSAI
- Award-winning: Awarded 2014 Functional Ingredients Editor’s Choice Award for Best Science (Curcumin C3 Reduct® overcome absorption barrier that regular curcumin must go through)
- Patents No. US6653327, AU2006235807, EP1171144, EP1328263, NZ514884
BioPerine® Black Pepper Extract:
- Standardised to ≥ 95% piperine
- Highly safe. Granted GRAS status after a comprehensive review of safety and toxicology data by an independent panel of scientists with international repute.
- Research proven safety and efficacy
- Long-standing ingredient. Introduced in the marketplace since 2 decades ago to enhance bioavailability of other nutrients
- Kosher and Halal certified
- Patented in US, Europe, Japan and Canada
OptiMSM®:
- Comprised of 34% bioavailable sulfur - the richest source known to man
- Highly safe. The only GRAS-designated MSM on the market. There is no known evidence of interactions between OptiMSM® and pharmaceuticals, herbs, vitamins or minerals.
- Research proven. Backed by numerous pre-clinical and clinical studies for safety and efficacy
- High quality. Non-GMO, gluten-free, allergen-free, non-shellfish-derived, no banned substances and vegan MSM backed by extensive toxicology data.
- High purity. A proprietary multi-stage distillation process ensures a 99.9% pure product to guarantee a consistent, high-quality form of MSM
- High consistency: 25+ years of manufacturing expertise backed by ISO 9001:2015 registration, FSSC22016 certification, HACCP and cGMP compliance
- Kosher and Halal certified
2 capsules daily after meal.
The bioavailability of various boswellic acids, especially AKBA was shown to be significantly enhanced by concomitant administration of a fat-containing meal (e.g. fried eggs, bacon, milk etc.)
Caution: Dietary supplements are not a substitute for a healthy diet. If you are pregnant, nursing or taking any medication, please consult your physician before consuming any supplements. Discontinue use 2 weeks before surgery.
Storage: Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
This product is not intended to diagnose, treat, cure or prevent any disease.
Research-proven Health Benefits of Key Ingredients
The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.
By using the Site, you agree that you have read and acknowledge the above and the Terms of Use for this Site.
1) Support healthy inflammatory response in joints
Study 1: Human leukocyte elastase (HLE) is known to trigger inflammation and pain within the joints. It has been suggested to attribute to rheumatoid arthritis due to its aggressive and destructive properties. In this in vitro study, boswellic acid AKBA was found to significantly inhibit HLE, thereby reducing joint inflammation and pain.
Study 2: In an in vitro study, Boswellia serrata extract was found to significantly reduced and normalised the production of pro-inflammatory factors - nuclear transcription factor κB (NF- κB), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cartilage cells.
Study 3: NF-ĸB is the master regulator of inflammation and plays a role in a wide variety of pathological conditions. In an in vitro study, cells were pre-incubated with curcumin for 60 minutes followed by PMA or H2O2 for 30 minutes and then tested for NF-ĸB activation. Curcumin was found to completely block PMA and H2O2-induced activation of NF-ĸB, indicating curcumin is a general suppressor of NF-ĸB activation.
Study 4: Interleukin (IL)-6 (IL6) and prostaglandin E2 (PGE2) promote inflammation and play a role in the development of rheumatoid arthritis (RA). In an in vitro study, anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated synovial cells derived from patients with rheumatoid arthritis (RA). Piperine was shown to suppress the production of IL-6 and PGE2 in a dose-dependent manner.
2) Support joint comfort & active mobility
Study 1: In a clinical trial, 49 subjects with knee osteoarthritis were orally administered either 1.125g MSM or placebo 3 times daily for 12 weeks. Taking MSM for 12 weeks showed an improvement in pain, stiffness and physical function.
Study 2: In a clinical trial, 100 patients with hip and/or knee osteoarthritis were orally administered a daily dosage of total 6g (3g twice daily) of MSM or placebo for 26 weeks. Compared to placebo, the MSM group showed significant improvement in physical symptoms and performance of daily living activities.
Study 3: In a clinical trial, 22 healthy adults were randomised to take either OptiMSM® or a placebo at 3g/day for 21 days before running a half marathon and two days after. Pain levels were recorded using a 100 mm Visual Analogue Scale (VAS) for both joint and muscle pain. OptiMSM® supplementation for 3 weeks reduced post-exercise joint and muscle pain compared to placebo.
Study 4: Boswellia serrata extract (50mg/kg) was administered to subjects for 21 days after the induction of arthritis (joint inflammation). When compared to control, Boswellia-treated group was found to be significantly decreased in edema (swelling) volume (p < 0.01). The study concluded that Boswellia serrata could be an effective adjuvant for arthritis management.
Study 5: Subjects with paw pain and arthritic ankle were orally administered piperine at 20 and 100 mg/kg/day for 8 days which resulted in significantly reduced pain and arthritic symptoms. Furthermore, piperine was also shown to significantly reduce the inflammatory area in the ankle joints. These results suggest that piperine could suppress inflammation and pain for those with joint problems.
3) Protect healthy joint structures
Patients with rheumatoid arthritis (RA) who experienced joint pain showed higher levels of serum hyaluronic acid1, suggesting an outflow from cartilaginous tissue. In this study, healthy adults with knee pain who consumed 100 mg/day of Boswellin® Super for 8 weeks showed lower levels of serum hyaluronic acid than those in the placebo group. This suggests the potential use of Boswellin® Super in protecting cartilage and alleviating pain in rheumatoid arthritis.
4) Synergistic benefits of combined ingredients
a) Curcumin and Boswellia extract
Study 1: In a randomised, double-blind, placebo-controlled trial, 201 patients with osteoarthritis (OA) were orally administered placebo, curcumin (Curcuma longa) or its combination with boswellic acid (Boswellia serrata) daily for 12 weeks and their conditions were evaluated at baseline and week 12. Both preparations resulted in a reduction of pain-related symptoms, but a combination of curcumin and boswellic acid was more effective, presumably due to synergistic effects of curcumin and boswellic acid.
Study 2: A combination of turmeric and boswellia extracts were also shown to be more effective in reducing pain than NSAID, which is a drug commonly prescribed for joint disorders.
In a clinical trial, osteoarthritic patients (age 18 - 65 years) were orally administered a CB formulation consisted of 350mg Curcuma longa (turmeric) extract (containing 70% curcumin, 17% demethoxycurcumin, 3.5% bisdemethoxycurcumin and 7.5% turmeric essential oils) and 150mg Boswellia serrata extract (containing 75% boswellic acids and 10% AKBA) in 500mg hard gelatin capsule twice daily or NSAID 100mg capsule twice daily for 12 weeks. The turmeric + Boswellia formulation was found to be more successful than for symptom scoring and clinical examination.
b) Curcumin and BioPerine®
Following oral administration, curcumin showed poor absorption resulting in low blood concentration (traces) and most of them are excreted in the faeces. However, several studies have shown that the presence of BioPerine® (an extract from black pepper fruits Piper nigrum) helped increase the bioavailability of Curcumin.
Study 1: In a test, curcumin concentration in blood serum was shown to increase significantly at 1 and 2 hours following administration of a combination of curcumin and BioPerine®.
Study 2: In a clinical trial, 10 healthy volunteers were first administered 2000 mg curcumin, followed by a two-week break before a second administration of 2000 mg of curcumin and BioPerine® (20 mg) combination. BioPerine® was shown to enhance the bioavailability of curcumin with curcumin serum concentration increased by 20-fold or 2000% compared to curcumin alone. BioPerine® inhibits metabolism and elimination in intestine and liver and thus, increasing the bioavailability of curcumin.
Cervical spondylosis is also referred to as arthritis of the neck. While it used to be an age-related wear and tear, it is now affecting young adults who are constantly looking down at their handphones or tablets. As the head tilts forward, the weight of the head can increase by up to 6x!
Some may even experience tingling or numbness down the hands, weakness in the grip strength, pain in the shoulder blades or over the skull. These may be referred pain from cervical spondylosis, resulting in pain in other parts of the body when the causation is actually from the neck region.
Tilting the head backwards and looking up will compress the nerve and inflame the nerve root further. Instead, do a chin tuck or tilt the head forward (to look at your feet).
Also, natural botanical extracts such as Boswellia and Curcumin have been shown to effectively combat inflammation and slow its progression. FlexC MAX EX, contains a clinically-proven functional dosage of these extracts in the highest quality grade, helping to greatly alleviate pain, stiffness, and loss of neck movement.
Ageing, unhealthy diet and lifestyle, stress, environmental factors and overactive immune response are risk factors that promote chronic inflammation – a persistent inflammation that can have long-term effects on the whole body. Pain in the body, especially at the joint, is one of the most common symptoms of chronic inflammation. Joint discomfort includes joint pain, stiffness, swelling and some degree of disability. There are several factors that can increase the risk.
What triggers joint discomfort
Joint discomfort includes joint pain, stiffness, swelling and some degree of disability. There are several factors that can increase the risk of joint discomfort:
1. Ageing
Ageing people are susceptible to soreness and aches when they climb stairs, walk or exercise. Natural deterioration of the body can lead to cartilage loss and inflammation which results in a vicious cycle of joint pain.
2. Daily Walking
A lifetime of walking can cause wear and tear on the cartilage, the synovium can become inflamed and thickened. This leads to cartilage loss which causes the bones to rub against each other and resulting in pain, swelling and reduced range of motion.
3. High-impact exercises
Though exercises are good for health, they can also stress the joints. High-impact exercises such as soccer, running, hockey, etc, are likely to cause injuries to the joints, leading to inflammation and damage to the cartilage. This may result in severe pain and limited range of motion.
4. Overweight
Overweight individuals are at higher risk of developing joint problem as their weight would stress and wear out the joint cartilage, and leading to inflammation. Repeated cycles of inflammation worsens the cartilage loss and develop into chronic joint pain and swelling.
5. Oxidative Stress
Oxidative stress arises due to an imbalance between free radical production and antioxidant protection. Inflammation triggered by oxidative stress can induce cartilage damage, causing joints to become painful and stiff, with a reduced range of movement.
6. Overactive immune response
An overactive immune system will attack and damage the body’s own tissues including those in the joints, thereby leading to inflammation, swelling and pain. If left untreated, the inflammation can gradually cause permanent joint damage.
Problems Associated with Long-Term Use of
Medication for Pain Relief
Readily available nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and naproxen are the most-used medications to ease joint pain, stiffness and swelling. Nonetheless, the use of NSAIDs is commonly associated with gastrointestinal side effects (abdominal pain, ulcers, bleeding etc). Even worse, these medications have been suggested to increase the rate of cartilage breakdown and speed up the need for joint replacement (Journal of Prolotherapy 2(1): 305-322 (2010)).
Boswellin® Super Bowsellia Extract - 30% AKBA
Boswellin® Super is a standardised herbal extract from the gum resin of Boswellia serrata (Indian frankincense). Boswellia extract had been used as an anti-inflammatory and painkiller in Asian and African folk medicine for centuries. Among the four bowsellic acids in the extract, acetyl-11-keto-β-boswellic acid (AKBA) is most powerful in suppressing a pro-inflammatory enzyme to help provide relief for discomfort and support prevention of cartilage loss.
Curcumin C3 Reduct® Turmeric Root Extract
Turmeric is a spice and medicinal herb popularly used in India to treat joint inflammation, sprains, swelling caused by injury, asthma and allergic conditions. Its main active ingredient, Curcumin, is a powerful antioxidant with anti-inflammatory property. Curcumin C3 Reduct® is extracted from the dried rhizomes (underground stems) of turmeric (Curcuma longa) (final extract ratio 100:1) and standardised for a minimum 95% tetrahydrocurcuminoids (THCs).
Research showed that THC can be absorbed more easily from the gastrointestinal tract compared to curcumin (J Nutr. 2001. 31: 2090-2095). The curcumin ingested will be converted by E. coli in the human intestines into tetrahydrocurcumin before absorption and the resulting THC (and not curcumin) is the one that is responsible for various biological functions associated with curcumin in the human body. Since Curcumin C3 Reduct® (tetrahydrocurcumin) is already in the pre-converted form, the absorption barrier has been overcome and this makes it 250x more potent than regular curcumin.
BioPerine® Black Pepper Extract
BioPerine® is a standardised black pepper (Piper nigrum) extract used for over 20 years to enhance the bioavailability of an ingredient. It may be co-administered with various nutrients to enhance their absorption by at least 30%.
OptiMSM®
MSM (methylsulfonylmethane) is an excellent source of sulphur, an important building block for protein synthesis and essential nutrient for the maintenance of healthy joints, tendons, ligaments, skin and other connective tissue.
Produced using multi-stage distillation process, OptiMSM® is the purest (99.9% purity), safest, and most consistent MSM in the world. It is easily assimilated into the body to support healthy cartilage, protect joints, manage swelling and pain, support a normal range of motion, as well as promote healthy skin. OptiMSM® also helps deter the accumulation of oxidative damage developed as a result of ageing and stress.
✔ Relieve aches and pains in joints and body
✔ Maintain joint and muscular health
✔ Support body's natural tissue repair process
✔ Support natural recovery from digestive discomfort
✔ Maintain healthy brain, memory and mood
✔ Maintain heart health, overall circulation and liver health
✔ Promote healthy skin and combat signs of premature ageing due to free radicals
✔ Reduce the need for pain medications such as NSAIDs
- Joint discomfort – knee pain, neck and back pain, shoulder pain, hip pain, wrist pain, foot/ankle pain (e.g. pain, stiffness, swelling, limited range of motion)
- Muscle discomfort – Pain, strains, spasm
- Middle-aged and the elderly – pain and stiffness due to joint and cartilage degeneration
- Overweight individuals – knee pain due to weight burden on the joints
- Physically active individuals – pain from excessive training or injuries
- Inflammation-related conditions – migraine, heart issues, abdominal pain, chest pain, constant fatigue, allergies etc.
- History of joint injuries or fractures
Contents: 60 veggie caps
1) Support joint comfort & active mobility
In a randomised, double-blind, placebo-controlled trial, 47 healthy adults with knee pain were randomised to consume a daily capsule containing either 100 mg/day of Boswellin® Super Boswellia serrata extract or a placebo for 8 weeks. Their knee pain was evaluated at baseline, 4 weeks and 8 weeks intervention. Compared with baseline (before treatment), the group consuming Boswellin® Super showed significant improvement in knee-pain relief after 8 weeks of intervention.
2) Support healthy inflammatory response
Study 1: Leukotrienes are inflammatory molecules produced by enzyme 5-lipoxygenase (5-LO). In this vitro study, boswellic acid AKBA was found to inhibit 5-LO inflammatory activity, thereby suppressing the production of leukotrienes and inflammatory response.
Study 2: Both curcumin and THC showed potent anti-inflammatory effects at low doses, but THC was effective at a much lower dose. This implies that THC (Curcumin C3 Reduct®) is more effective than curcumin (Curcumin C3 Complex®) in supporting healthy inflammatory response.
Study 2: Curcuminoid is a strong antioxidant with potent anti-inflammatory property, thus, may be helpful in the treatment of OA.In a randomised, double-blind and placebo-controlled trial, 40 patients with mild-to-moderate knee osteoarthritis were administered either 3 capsules of Curcumin C3 Complex® formulation (500 mg Curcumin C3 Complex®* and 5 mg BioPerine® combination per capsule) or placebo daily for a period of 6 weeks. Supplementation with Curcumin C3 Complex® - BioPerine® resulted in significant improvements in systemic oxidative stress biomarkers, which further validates antioxidant effects of curcuminoids in OA. Curcumin C3 Complex® - BioPerine® reduces oxidative stress in osteoarthritis.
*Curcumin C3 Reduct® in newer version of FlexC MAX EX was designed to deliver the benefits of Curcumin C3 Complex®.
Study 1: Tetrahydrocurcumin (THC) is a powerful antioxidant that helps prevent formation of free radicals and quench already preformed free radicals into non-free radical’s form). Research found that THC has higher antioxidant activity than vitamin C (commonly used antioxidant), as well as curcumin.
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