2x FlexC MAX EX + FlexC CARE EX

Active ingredients per 2 capsules: 100mg Boswellin® Super Boswellia serrata Extract, 400mg Curcumin C3 Reduct® Turmeric Root Extract, 10mg BioPerine® Black Pepper Extract, 790mg OptiMSM®.

Unique properties of key ingredients

Boswellin® Super Boswellia Extract:

• Standardised to 30% AKBA
• Research proven safety and efficacy
• Kosher and Halal certified
• Patented in US, Europe and globally, pertaining to specific applications of boswellic acids

Curcumin C3 Reduct®

• Derived from Curcumin C3 Complex®
• Standardised to 95% Tetrahydrocurcuminoids, which is the colourless hydrogenated product derived from the curcuminoids (primarily curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)), which is extracted from the rhizomes of Curcuma longa.
• Highly safe. The safety of oral administration of THC has been established in humans.

THC is highly safe

In the clinical trial, 300mg of THC was administered to 20 healthy human volunteers once daily for 28 days and 15 vital parameters were evaluated. Results showed that THC was safe for oral administration:

• High absorption and bioavailability : THC is more easily absorbed in the intestines compared to curcumin.

THC is more easily absorbed in the intestines than curcumin

In this experiment, one group of mice was fed with a diet containing 0.5% curcumin, while the other group was fed with a diet containing 0.5% THC for 1 month. At the end of the study, concentration of THC was higher than curcumin in liver and blood serum in both groups. Hence, it can be concluded that orally administered THC can be absorbed more easily in the intestines compared to curcumin.  

• Superior stability: THC is more stable than curcumin in physiolocal pH.
• High efficacy : It is not the curcumin, but THC (converted from curcumin) that is responsible for biological functions in the body.
• Approved by authority in Canada: Curcumin C3 Reduct® has received approval from NNHPD (Natural and Non--prescription Health Product Directorate), the regulatory authority in Canada.
• High credibility: Kosher and Halal certified, GMO-free, TSE-BSE-free, Nanotechnology-free, ISO 22000:2005, FSSC 22000:2011, NSF GMP, FDA-Audited, FSSAI
• Award-winning: Awarded 2014 Functional Ingredients Editor’s Choice Award for Best Science (Curcumin C3 Reduct® overcome absorption barrier that regular curcumin must go through) 
• Patents No. US6653327, AU2006235807, EP1171144, EP1328263, NZ514884

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BioPerine® Black Pepper Extract:

• Standardised to ≥ 95% piperine
• Highly safe. Granted GRAS status after a comprehensive review of safety and toxicology data by an independent panel of scientists with international repute.
• Research proven safety and efficacy
• Long-standing ingredient. Introduced in the marketplace since 2 decades ago to enhance bioavailability of other nutrients
• Kosher and Halal certified
• Patented in US, Europe, Japan and Canada

OptiMSM®:

• Comprised of 34% bioavailable sulfur - the richest source known to man
• Highly safe. The only GRAS-designated MSM on the market. There is no known evidence of interactions between OptiMSM^® and pharmaceuticals, herbs, vitamins or minerals.
• Research proven. Backed by numerous pre-clinical and clinical studies for safety and efficacy
• High quality. Non-GMO, gluten-free, allergen-free, non-shellfish-derived, no banned substances and vegan MSM backed by extensive toxicology data.
• High purity. A proprietary multi-stage distillation process ensures a 99.9% pure product to guarantee a consistent, high-quality form of MSM
• High consistency: 25+ years of manufacturing expertise backed by ISO 9001:2015 registration, FSSC22016 certification, HACCP and cGMP compliance
• Kosher and Halal certified

2 capsules daily after meal.

The bioavailability of various boswellic acids, especially AKBA was shown to be significantly enhanced by concomitant administration of a fat-containing meal (e.g. fried eggs, bacon, milk etc.)

Caution: Dietary supplements are not a substitute for a healthy diet. If you are pregnant, nursing or taking any medication, please consult your physician before consuming any supplements. Discontinue use 2 weeks before surgery.

Storage: Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
This product is not intended to diagnose, treat, cure or prevent any disease.

Q: How does FlexC MAX EX help relieve joint pain?
A: FlexC MAX EX is a vegetarian, extra strength & fast-acting formula made with curated patented bioactive extracts in functional dosage for maximum potency. Comprising natural ingredients of Boswellin® Super Boswellia serrata Extract, Curcumin C3 Reduct® Turmeric Root Extract, BioPerine® Black Pepper Extract and OptiMSM®, their synergistic effects help support a healthy inflammatory response and antioxidant protection to help relieve joint discomfort, support natural tissue repair process and support healthy joint structures. Besides joint pain, FlexC MAX EX also provides fast relief from body discomfort and supports overall wellness.

Q: I always experience muscle and joint pain after each high-intensity training. Can FlexC MAX EX help relieve the pain quickly?
A: Yes, it can. Most people would experience pain relief within 3 days though the results may vary between individuals. Research shows that OptiMSM® - one of the active ingredients in FlexC MAX EX - is effective in reducing post-exercise muscle and joint pain.

Q: I do not have joint pain. Can I take FlexC MAX EX to maintain joint and overall body wellness?
A: Yes, you can. In addition to supporting joint comfort, FlexC MAX EX also nourishes damaged cartilage, tendon and ligaments in the joints to support self-healing, thereby maintaining healthy joint structures and range of motion. Besides joints, FlexC MAX EX contains antioxidant which deters the accumulation of oxidative damage developed as a result of ageing and stress on the body. Since inflammation is associated with a wide range of health problems, the anti-inflammatory properties of FlexC MAX EX is beneficial in supporting overall body wellness. For general health maintenance, the suggested dosage is 1 capsule daily.

Q: What is extract standardisation and why is it important for an herbal supplement?
A: Extract standardisation is a quality marker to ensure the ingredients in a supplement are of the same quality and purity in every batch. A standardised extract has one or more bioactive compounds in a guaranteed amount and is usually listed in percentages. All 3 herbal ingredients in FlexC MAX EX – Bowellia, turmeric root and black pepper extracts are standardised and hence are guaranteed of consistent potency.
In contrast, unstandardised supplements may not yield consistent effects. If a product does not have a listed standardised percentage, then it could be occurring in any amount, including one that is too low to produce any effects. Besides, unstandardised supplements may pose risks of overdose or dangerous side effects.

Q: What is the difference between turmeric, curcuminoids, curcumin and tetrahydrocurcumin (THC)?
A: Turmeric is a bright yellow spice powder that derives from the root of a plant known as Curcuma longa. Curcuminoids are a family of active compounds within turmeric, this includes curcumin (major constituent), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Tetrahydrocurcumin (THC) is a product converted from curcumin by enzyme's action of E. coli bacteria. In the human body, curcumin in the intestines is converted into THC by E. coli and that the produced THC is responsible for various psychological activities in the body. THC was found to be more potent than curcumin in different aspects, including antioxidative activity.

Q: Curcumin is known to have low bioavailability. What is bioavailability and how does FlexC MAX EX overcome this?
A: Bioavailability refers to the capability of a nutrient in having an active effect on the body after it has been introduced via blood circulation. The low bioavailability of curcumin is mainly caused by low water solubility, poor absorption by the body and rapid metabolism and excretion from the body. Instead of curcumin, FlexC MAX EX is formulated with tetradhydrocurcumin (THC), the body-ready form of curcumin, which has higher absorption and bioavailability than curcumin. Besides, this proprietary formula also contains BioPerine® black pepper extract to further enhance absorption.

Q: Can I take FlexC MAX EX alongside painkillers, medicines or NSAIDs?
A: Yes, you can. Please take FlexC MAX EX at least 2 hours apart from painkillers/NSAIDs to ensure the efficacy of FlexC MAX EX is not compromised. A study showed that significantly higher numbers of subjects reporting decreased or no use of NSAID after taking Curcumin C3 Reduct®* (one of the key ingredients in FlexC MAX EX) (Phytother Res 28: 1625 – 1631 (2014)). Another study showed the combination of turmeric and boswellia extracts was more effective than NSAID in reducing pain (Mol Med Rep 8(5): 1542-1548 (2013)), this suggests the efficacy of FlexC MAX EX in managing joint discomforts.

*Curcumin C3 Reduct® in newer version of FlexC MAX EX was designed to deliver the benefits of Curcumin C3 Complex®.

Q: Is FlexC MAX EX safe for use during pregnancy and breastfeeding?
A: FlexC MAX EX has not been studied for use during pregnancy and breastfeeding. If you are pregnant or breastfeeding, we strongly advise you to consult your physician before taking any supplements.

Q: Is FlexC MAX EX safe to be taken for long-term?
A: Yes, it is safe. FlexC MAX EX is formulated with ingredients that have been proven safe and granted GRAS (Generally Recognised as Safe) status. If you have joint concerns or other ongoing health concerns, you are recommended to take 2 capsules of FlexC MAX EX daily for a minimum of 3 months to observe best results. Thereafter, you may want to reduce to 1 capsule daily for general maintenance. 

Q: When is the best time to take FlexC MAX EX?
A: FlexC MAX EX is best to be taken after meals, especially meals containing fats. Studies showed the bioavailability of AKBA, a bioactive compound in Boswellia extract was significantly enhanced by a fat-containing meal (e.g. fried eggs, bacon, milk etc). Fat in foods also helps improve the absorption of tetrahydrocurcumin (a bioactive compound in turmeric root extract) in the body. Hence, taking FlexC MAX EX after meals would maximise its potency and efficacy.

Q: Who should take FlexC MAX EX?
A: FlexC MAX EX is highly recommended for those suffering from joint discomforts such as joint pain, stiffness, swelling or decreased range of motion. It is also beneficial for those with high risks of wear and tear on the cartilage; this includes the middle-aged and elderly, overweight individuals as well as athletes or the physically active. Besides joint pain, FlexC MAX EX is also effective for muscle pain, strain, spasm or past history of joint injury or fractures. Since FlexC MAX EX supports healthy inflammatory response / immunological functions, people who suffer from inflammation-related conditions such as heart problems, allergy, asthma, inflammation of digestive tract, etc can also benefit from taking to FlexC MAX EX.

Q: How effective is FlexC MAX EX?
A: The efficacy of FlexC MAX EX has been proven in multiple clinical trials. Boswellia reduced body ache up to 234%. A combination of Curumin C3 Complex®* and BioPerine® reduced joint pain by 38%, stiffness by 85% and increased mobility by 41% in patients with osteoarthritis. These improvements were noticed when the extracts were studied individually. Hence, the combined formulation and synergistic effects of all extracts in FlexC MAX EX is expected to support greater improvements. Most users could feel the difference within 3 days, though this may vary between individuals.

*Curcumin C3 Reduct® in newer version of FlexC MAX EX was designed to deliver the benefits of Curcumin C3 Complex®.

Research-proven Health Benefits of Key Ingredients

The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.

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1) Support healthy inflammatory response in joints

Study 1: Human leukocyte elastase (HLE) is known to trigger inflammation and pain within the joints. It has been suggested to attribute to rheumatoid arthritis due to its aggressive and destructive properties. In this in vitro study, boswellic acid AKBA was found to significantly inhibit HLE, thereby reducing joint inflammation and pain.

Study 2: In an in vitro study, Boswellia serrata extract was found to significantly reduced and normalised the production of pro-inflammatory factors - nuclear transcription factor κB (NF- κB), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cartilage cells.

 Study 3: NF-ĸB is the master regulator of inflammation and plays a role in a wide variety of pathological conditions. In an in vitro study, cells were pre-incubated with curcumin for 60 minutes followed by PMA or H₂O₂ for 30 minutes and then tested for NF-ĸB activation. Curcumin was found to completely block PMA and H₂O₂-induced activation of NF-ĸB, indicating curcumin is a general suppressor of NF-ĸB activation.

Study 4: Interleukin (IL)-6 (IL6) and prostaglandin E₂ (PGE₂) promote inflammation and play a role in the development of rheumatoid arthritis (RA). In an in vitro study, anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated synovial cells derived from patients with rheumatoid arthritis (RA). Piperine was shown to suppress the production of IL-6 and PGE₂ in a dose-dependent manner. 

2) Support joint comfort & active mobility

Study 1: In a clinical trial, 49 subjects with knee osteoarthritis were orally administered either 1.125g MSM or placebo 3 times daily for 12 weeks. Taking MSM for 12 weeks showed an improvement in pain, stiffness and physical function.

Study 2: In a clinical trial, 100 patients with hip and/or knee osteoarthritis were orally administered a daily dosage of total 6g (3g twice daily) of MSM or placebo for 26 weeks. Compared to placebo, the MSM group showed significant improvement in physical symptoms and performance of daily living activities.

Study 3: In a clinical trial, 22 healthy adults were randomised to take either OptiMSM® or a placebo at 3g/day for 21 days before running a half marathon and two days after. Pain levels were recorded using a 100 mm Visual Analogue Scale (VAS) for both joint and muscle pain. OptiMSM® supplementation for 3 weeks reduced post-exercise joint and muscle pain compared to placebo.

 Study 4: Boswellia serrata extract (50mg/kg) was administered to subjects for 21 days after the induction of arthritis (joint inflammation). When compared to control, Boswellia-treated group was found to be significantly decreased in edema (swelling) volume (p < 0.01). The study concluded that Boswellia serrata could be an effective adjuvant for arthritis management.

 Study 5: Subjects with paw pain and arthritic ankle were orally administered piperine at 20 and 100 mg/kg/day for 8 days which resulted in significantly reduced pain and arthritic symptoms. Furthermore,  piperine was also shown to significantly reduce the inflammatory area in the ankle joints. These results suggest that piperine could suppress inflammation and pain for those with joint problems.

3) Protect healthy joint structures

Patients with rheumatoid arthritis (RA) who experienced joint pain showed higher levels of serum hyaluronic acid¹, suggesting an outflow from cartilaginous tissue. In this study, healthy adults with knee pain who consumed 100 mg/day of Boswellin® Super for 8 weeks showed lower levels of serum hyaluronic acid than those in the placebo group. This suggests the potential use of Boswellin® Super in protecting cartilage and alleviating pain in rheumatoid arthritis.

4) Synergistic benefits of combined ingredients

a) Curcumin and Boswellia extract

Study 1: In a randomised, double-blind, placebo-controlled trial, 201 patients with osteoarthritis (OA) were orally administered placebo, curcumin (Curcuma longa) or its combination with boswellic acid (Boswellia serrata) daily for 12 weeks and their conditions were evaluated at baseline and week 12. Both preparations resulted in a reduction of pain-related symptoms, but a combination of curcumin and boswellic acid was more effective, presumably due to synergistic effects of curcumin and boswellic acid.

Study 2: A combination of turmeric and boswellia extracts were also shown to be more effective in reducing pain than NSAID, which is a drug commonly prescribed for joint disorders. 

In a clinical trial, osteoarthritic patients (age 18 - 65 years) were orally administered a CB formulation consisted of 350mg Curcuma longa  (turmeric) extract (containing 70% curcumin, 17% demethoxycurcumin, 3.5% bisdemethoxycurcumin and 7.5% turmeric essential oils) and 150mg Boswellia serrata extract (containing 75% boswellic acids and 10% AKBA) in 500mg hard gelatin capsule twice daily or NSAID 100mg capsule twice daily for 12 weeks. The turmeric + Boswellia formulation was found to be more successful than for symptom scoring and clinical examination.

b) Curcumin and BioPerine®

Following oral administration, curcumin showed poor absorption resulting in low blood concentration (traces) and most of them are excreted in the faeces. However, several studies have shown that the presence of BioPerine® (an extract from black pepper fruits Piper nigrum) helped increase the bioavailability of Curcumin.

Study 1: In a test, curcumin concentration in blood serum was shown to increase significantly at 1 and 2 hours following administration of a combination of curcumin and BioPerine®.

Study 2: In a clinical trial, 10 healthy volunteers were first administered 2000 mg curcumin, followed by a two-week break before a second administration of 2000 mg of curcumin and BioPerine^® (20 mg) combination. BioPerine® was shown to enhance the bioavailability of curcumin with curcumin serum concentration increased by 20-fold or 2000% compared to curcumin alone. BioPerine® inhibits metabolism and elimination in intestine and liver and thus, increasing the bioavailability of curcumin.