FlexC PRO EX

10,300mg Peptan® Type I, II & III Collagen Peptides, 300mg OVOMET® Eggshell Membrane, 50mg Silica‐Rx99, 200mg Curcumin C3 Reduct® Tetrahydrocurcuminoids

Gluten-free. No fillers, binders, preservatives, additives, wheat, yeast, milk derivatives, artificial colouring or flavouring. 100% fat free.

CAUTION: If you have any existing medical condition, please consult your physician before consuming any supplements.

Store in a cool and dry place. Keep out of reach of children.

Soniwala, S. et al., 2018, Oral Hydrolyzed Type 2 Collagen Protects Against the OA of Obesity and Mitigates Obese Gut Microbiome Dysbiosis. Poster presentation at ORS 2018 and OARSI 2018Soniwala, S. et al., 2018, Oral Hydrolyzed Type 2 Collagen Protects Against the OA of Obesity and Mitigates Obese Gut Microbiome Dysbiosis. Poster presentation at ORS 2018 and OARSI 2018

Mix 1 sachet into 250ml of water or your favourite beverage (up to 100°C). Consume one sachet per day for at least 1 to 3 months for best results. To maintain healthy muscle mass, please take 1 sachet every morning.

Q: Why is FlexC PRO EX a better choice over other joint and bone supplements?
A: Our body structure is made up primarily of joints, bones, muscles, tendons and skin. Single-ingredient supplements like calcium, collagen, silicon or curcumin are single benefit specific and inadequate to help maintain a strong body structure. FlexC PRO EX is a multi-functional formula which combines the prowess of 4 highly researched ingredients - Peptan® Type I, II & III Collagen Peptides,  Silica-Rx99, Curcumin C3 Reduct® Tetrahydrocurcuminoids and OVOMET® Eggshell Membrane, to support healthy joints, bones, muscles, ligaments, tendons, skin, nails and hair. With multiple potent ingredients in one formula, it is 2.4x more effective than glucosamine and chondroitin, 1.9x more effective than undenatured collagen type II and 250x more potent than regular curcumin. It could help relieve joint discomfort in as soon as 5 days, increase cartilage by 25%, improve joint lubrication by 158%, increase skin hydration by 91, decrease the volume of wrinkles by 40% and increase hair strength by 13%.

Q: What makes FlexC PRO EX more superior to other collagen supplements?
A: Most collagen supplements in the market contain only one type of collagen peptides and are of larger molecular sizes which make them poor in absorption and bioavailability. FlexC PRO EX is different. It is formulated with Peptan® and OVOMET and contains types I, II, III, V, X collagen peptides in a single formula. Type I collagen is most common type of collagen, accounting for 90% of the collagen in the human body. This collagen is found in skin, hair, nails, bone, and ligaments and is particularly helpful in supporting healthy, youthful-looking skin. Type II collagen helps build cartilage & maintain gut lining. Type III collagen supports skin and bone health and forms part of arterial walls and hence, it is important for cardiovascular health. Type V and X collagens are less commonly found in supplements. Type V collagen is essential for the formation of new skin, bone and muscles, while type X is essential for the development of healthy bone and cartilage. Comprising multiple types of collagen, FlexC PRO EX is an excellent solution for joint, bone, muscle, tendon, ligament, skin, hair and nails. Processed via an advanced enzymatic hydrolysis process, these collagen peptides are of smaller molecular size (< 2000 Da), enabling excellent absorption and bioavailability to effectively boost collagen levels in multiple tissues.

Q: How does THC Curcumin C3 Reduct® differ from regular curcuminoids?
A: Formulated with minimum 95% tetrahydrocurcuminoids (THCs), Curcumin C3 Reduct® is 250X more potent than regular curcuminoids. Curcuminoids, which is yellowish colour, has to be converted in the body to THC form before they can be absorbed and utilized. THC, not curcumin, is responsible for various biological functions associated with turmeric in the body. These include supporting healthy inflammatory response, providing antioxidant protection, as well as supporting joint comfort and active mobility. As THC Curcumin C3 Reduct® is already in THC form (which is white in colour), it can be directly absorbed in the gut, making it more potent and fast-acting than regular curcuminoids. 

Q: What is the superiority and benefits of Silica-Rx99®?
A: Silica-Rx99® is a natural, 99% purity and water-soluble silica that is easily absorbed in the gut. It is particularly essential for healthy collagen, bone, skin, hair, nail and other connective tissues. Silica-Rx99® helps stimulate type I collagen synthesis and strengthen the collagen by cross linking collagen strands. In addition, it helps support healthy bone mineral density by promoting bone formation, triggering bone mineralization (calcium incorporated into bone) and reducing bone resorption (loss of calcium from bone). Furthermore, it helps maintain the integrity, elasticity and strength of body tissues, including bones, cartilage, tendons (which connect bone to muscle), ligaments (connecting two bones to form joints), skin, hair and nails.

Q: What is so unique about OVOMET® Eggshell Membrane?
A: Extracted using patented technology, OVOMET® is highly pure with over 95% of pure eggshell membrane. Free from gluten, OVOMET® is naturally rich in collagen (types I, V and X), chondroitin sulfate, glucosamine, hyaluronic acid, elastin and more than 500 different types of proteins. Combining the synergistic benefits of multiple biomolecules, 300 mg OVOMET® is 2.4X more effective than glucosamine & chondroitin, 1.9X more effective than undenatured collagen type II. This multiple-action and fast-acting ingredient could relieve joint discomfort as fast as 5 days. In addition, it supports healthy inflammatory response and tendon protection. 

Q: Do I need to take other supplements on top of FlexC PRO EX for joint and bone health?
A: Together with a healthy lifestyle and diet, one sachet of FlexC PRO EX is sufficient to maintain the health of your body structure. However, should you have any medical conditions, we advise that you consult your health practitioner before taking any supplements.
 
Q: Can I take FlexC PRO EX with other supplements or medications?
A: Yes. However we advise a 2 hour gap before or after medication so as not to compromise with the efficacy of FlexC PRO EX.
 
Q: Can I take FlexC PRO EX on a long-term basis?
A: Yes. powdered form FlexC PRO EX is free of coating or gelatin, unlike other tablet or capsule form of collagen, silica and curcumin supplements. It is also free of additives, coloring and fat-free. As our body and joints go through wear and tear daily, taking FlexC PRO EX on a regular basis helps to strengthen the body ‘s physical structure with added improvement to skin, hair and nails.

The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.

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FlexC PRO EX supports overall joint health.

1.1. Relieve Stiffness

Peptan® Collagen Peptides is effectve in improving joint stiffness. 94 women aged 40 to 70 with knee joint problems were administered 8g of Peptan® or placebo daily for a period of 6 months.

Peptan®-treated subjects showed 24% decrease in stiffness as reflected in the WOMAC** score

**WOMAC score is the standard international method for clinical assessment of joint health in patients.

Jiang J.X. et al., Agro FOOD Industry Hi Tech 2014 25: 19-23

Patents suffering from mild-to-moderate knee joint problems were administered with Curcumin C3 Complex® for 6 weeks. Curcumin C3 Reduct® was derived from Curcumin C3 Complex®.

Significant improvements in the stiffness and physical function scores were observed, compared to baseline (before treatment).

Curcumin helped relieve joint discomfort

​1.2. Improve Joint Flexibility

The Lysholm score is linked to the improvement of knee movement in everyday activities. Increased score value means improvement in the condition. Elderly women with knee joint problems who were given Peptan® for six months observed improvement.

1.3. Protect and Lubricate Joints
Study 1: In post-traumatic knee joint problems, joint injury triggers cartilage loss. In this study, subjects with post-traumatic knee joint problems were administered Peptan® IIm for 3 months. Peptan® IIm was shown to help protect the cartilage from further deterioration, as illustrated by the increased cartilage area. Besides, Peptan® IIm also promoted lubrication via the stimulation of proteoglycan production in cartilage cells, as shown by an increase in % of active cells.

Soniwala, S. et al., 2018, Oral Hydrolyzed Type 2 Collagen Protects Against the OA of Obesity and Mitigates Obese Gut Microbiome Dysbiosis. Poster presentation at ORS 2018 and OARSI 2018

Study 2: Similar protective effects were also seen on a model for obesity-associated knee joint problems combined with injury. Peptan® IIm supplementation for 3 weeks helped protect cartilage (as shown by an increase of cartilage area) and lubricate joint (as shown by an increase in % of active cells).

Soniwala, S. et al., 2018, Oral Hydrolyzed Type 2 Collagen Protects Against the OA of Obesity and Mitigates Obese Gut Microbiome Dysbiosis. Poster presentation at ORS 2018 and OARSI 2018

1.4. Provide antioxidant protection

Besides “mechanical stress”, oxidative stress also contributes to the development and progression of knee joint problems.

Tetrahydrocurcumin (THC) is a powerful antioxidant that helps prevent formation of free radicals and quench pre-formed free radicals into non-free radical form. Research found that THC has higher antioxidant activity than vitamin C (commonly used antioxidant), as well as curcumin.

Collagen is the main protein in bone, it makes up more than 90% of organic bone mass and provides the structural framework for mineral deposition. By forming long fibres, collagen provides strength and flexibility to the bones, to help them to resist bone fractures. The synergistic effects of collagen and silicon help promote stronger and healthier bones.

FlexC PRO EX supports strong and healthy bones, as proven in multiple in vitro, in vivo and clinical trials.

2.1. Restore Bone Mineral Density and Strengthen Bone

Study 1: Low bone mineral density results when bone resorption (transfer of calcium from bone tissue to the blood) exceeds bone formation. Peptan® Collagen Peptides helps restore bone mineral density.

Study 2: In a monitoring test, 8 women aged between 45 and 82 years old and one man aged 58 years old were administered Silica-Rx99TM (≥ 40mg silicon) daily for 6 months and their bone density was monitored. Surprisingly, all 9 participants showed an increase in bone density (100% efficacy). On average, the bone density increased 13%, including postmenopausal women. Notably, Silica-Rx99 worked 4 to 6 times faster than a specific calcium supplement for all 9 participants. In this test, one participant was suffering from weakens bone and her bone density kept decreasing despite taking prescribed drug. Nonetheless, her bone density increased after taking Silica-Rx99TM. Other than Silica-Rx99TM, there is no other silica products that can show such dramatic improvement in bone density in such a short period of time thus far. These groundbreaking findings have been published in Nippon Dental Newspaper and Medical Magazine Apolonia.

2.2. Stimulate Formation of Osteoblasts (bone cells)

An in vitro study showed Peptan® treatment promoted the formation of bone-forming cells (Osteoblasts) and stimulated their activity, while suppressing the differentiation of osteoclasts (bone-resorbing cells). Hence, osteoclasts could not develop into mature and fully functional cells that break down bone mass. The control protein (BSA) did not demonstrate the same effect.

 Peptan® Increases the Number of Bone Cell

Guillerminet, F. et al, 2012. Osteoporosis International 23 (7): 1909-1919

To assess this efficacy on humans, 10 healthy volunteers fasted for 12 hours and were administered with 25g Peptan® collagen peptides or 25g hydrolysed casein dissolved in water. Results confirmed that collagen-enriched blood serum helped increase osteoblast activity, support bone formation and decrease osteoclastogenesis, which is responsible for degradation of bone cells.

Sarcopenia – the loss of muscle mass and function is a common concern that comes with age. Strong muscles are important for supporting bones and keeping the body mass from taxing the joints. They also help to keep joints in correct alignment. FlexC PRO EX is beneficial for preserving lean body mass and supporting muscle tissue recovery.

3.1. Strengthen Tendon

Collagen peptides were administered daily for 8 weeks and a significant increase in collagen fibril diameter was observed. This indicates that collagen peptides help to strengthen the Achilles tendon.

Minaguchi J. et al. Journal of Nutritional Science and Vitaminology 2005 51: 169-174

3.2. Preserve Lean Body Mass

Nitrogen balance is the key to muscle growth. Negative nitrogen balance (nitrogen loss is greater than nitrogen intake) destroys muscle, causing its degeneration. In a double-blind, crossover trial to compare nitrogen balance in elderly women aged 65 to 85. One group had whey protein supplemented to their diet and the experimental group had collagen peptides. Results showed collagen peptides helped maintain nitrogen balance and preserve lean body mass.

Collagen peptides is beneficial for muscle health

FlexC PRO EX helps to counteract the effects of ageing to promote a youthful appearance by erecting and restructuring the skin’s collagen network from within.

4.1. Reverse the Signs of Ageing Skin

By boosting and reversing the structural damage of the fatigued skin, Peptan® improves the quantity of skin collagen and subsequently reduces wrinkles, fine lines and restores tone and texture.

Peptan® improves skin firmness

In a randomised, placebo-controlled, double-blind clinical trial,106 women aged 40 to 65 received 10g of Peptan® or placebo per day for a period of three months. Results demonstrated stronger collagen structure and firmer skin after the intake of Peptan®.

After 4 weeks of Peptan®

After 12 weeks of Peptan®

Asserin, J. et al. Journal of Cosmetic Dermatology 2015, doi: 10.1111/jocd.12174

4.2. Smooth Fine Lines and Wrinkles

The study was conducted in France to evaluate the effects of oral Peptan® Collagen Peptides on cutaneous properties. 47 women aged 35 to 55 were given 10g of Peptan® powder mixed with liquids for 84 days observed significant decrease in the volume and depth of wrinkles.

Reduction in the depth and volume of the wrinkles

Study 2008 – A00654 – 51

4.3 Boost Skin Hydration Level

Peptan® in FlexC PRO EX replenishes the skin’s collagen reserves to keep dry skin smooth and hydrated.

In a randomised, placebo-controlled, double-blind clinical trial, 33 women received 10g of Peptan® or placebo per day for two months. It was found that Peptan® helps counteract the appearance of dry skin by increasing the skin's moisture levels.

Skin hydration level- Corneometer measurement

Asserin, J. et al. Journal of Cosmetic Dermatology 2015, doi: 10.1111/jocd.12174

4.4. Reduce Visibility of Pores
In a randomised, double-blind, placebo-controlled clinical trial, 30 healthy Brazilian women aged 45 to 60 years old received 5g Peptan® Collagen Peptides (bovine) daily for 3 months, and another 30 women received placebo control. Results showed significant improvements in the overall appearance of the skin, which was characterised by a reduction of the visibility of pores in the region of the cheekbones, a decrease in wrinkles around the eyes, nose and mouth, a clear increase of the density of the dermis, which contains the strength-providing collagen layer of the skin.

Rousselot unpublished study

Collagen deficiency is evident in the hair and nails. Especially in the ageing years, falling hair, hair breakage and thinner nails are common problems. Peptan® Collagen Peptides help strengthen hair shaft, promote hair and nail growth, and improve the quality to reduce breakage during the lifespan of the hair. It promotes:

• Healthier, stronger and faster-growing hair and nails

• Improved thickness of nails with less splintering

In a randomised, double-blind, placebo-controlled clinical trial, 60 healthy Brazilian women aged 45 to 60 years old received either 5g Peptan® Collagen Peptides or placebo daily for 3 months. Compared to the placebo group, Peptan® supplementation resulted in an increase of the mechanical strength of the hair, which is linked to improved hair cortex. This improvement is especially beneficial for aging hair.

Rousselot unpublished study

• FlexC PRO EX protects muscles and joints from exercise-induced injury, during and after exercise.
• 2 hours post-exercise – Reduces muscle soreness and supports faster recovery.

• Continual use of FlexC PRO EX - Expect a stronger body structure and youthful-looking.

Please note that results may vary according to individual’s body condition.

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