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The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.
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Research Proven Health Benefits of Nattokinase NSK-SD®:
✓ Support clear blood vessels
(Balancing clotting system naturally and thus, does not increase bleeding risk)
In a human clinical trial, healthy young men (22.3 ± 0.6 years old) received either a single dose of 2,000 FU nattokinase NSK-SD® or placebo and blood samples were collected and analysed. Results show that nattokinase NSK-SD® enhances fibrinolysis (breaking down of blood clots) and anticoagulation.
✓ Support healthy blood viscosity
In an in vitro study, blood samples from healthy adult individuals were incubated with nattokinase at various doses. Red blood cell (RBC) aggregation was then assessed. The decrease of RBC aggregation suggests its potential benefits on patients having or at risk for cardiovascular diseases.
✓ Improves blood flow
In a human clinical trial, healthy subjects (30s – 40s years old) in the fasting state received 2,000 FU nattokinase NSK-SD® and their blood flow was measured. After a 2-week break, the same subjects received placebo under the same condition. Results showed that nattokinase NSK-SD® increased blood flow, suggesting a possible use of NSK-SD® for healthy circulation.
Blood flow of 3 subjects. The blood flow increases in the order of blue →green →yellow→ orange → red.
Study 2: In another study, the effects of nattokinase NSK-SD® on in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin, a medicine that helps prevent blood clots in arteries. Nattokinase NSK-SD® moderately inhibits platelet aggregation and delays thrombosis following oxidative arterial wall injury, suggesting its beneficial effect on improving blood flow without adverse effects.
Platelet-rich plasma was incubated with nattokinase NSK-SD® and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analysed. Nattokinase significantly inhibited both the collagen- and thrombin-induced platelet aggregation.
Subjects were orally administered with nattokinase NSK-SD® or aspirin for 1 week, and their major blood vessels in the neck were exposed. Arterial thrombosis (blood clot formation in artery) was induced by applying FeCl3 outside the arterial wall for 10 min, and the blood flow was monitored. Nattokinase delayed the FeCl3-induced arterial blockage in a dose-dependent manner with a high dose (500 mg/kg) of nattokinase fully suppressed the blockage, as achieved with aspirin (30 mg/kg).
✓ Supports healthy blood pressure
Study 1: In a human clinical trial, subjects (20 – 80 years old) with pre-hypertension or stage 1 hypertension and initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg were given 2,000 FU nattokinase NSK-SD® or placebo per day for 8 weeks. Compared to placebo, nattokinase NSK-SD® reduced both systolic and diastolic blood pressure (DBP), suggesting nattokinase may play a critical role in preventing and treating hypertension or high blood pressure.
Study 2: In a human clinical trial, subjects (18 – 85 years) with elevated blood pressure (BP; systolic BP 130 or diastolic BP 90 mmHg) consumed 2,000 FU/day nattokinase NSK-SD® or placebo for 8 weeks and their blood was collected. Consumption of NSK-SD® was associated with a reduction in both systolic and diastolic BP as well as von Willebrand factor (vWF), a cardiovascular risk marker.
✓ Support good cardiovascular health
The American Heart Association justifies C-reactive protein (hs-CRP) as an independent clinical marker for cardiovascular disease (CVD) risk.
In a human clinical trial, subjects with cardiovascular risk factors received one dose of 2,000 FU nattokinase NSK-SD® and their blood was tested. Nattokinase demonstrated the ability to normalise levels of hs-CRP.
✓ Support cardiovascular health along with blood thinners
Study 1: In a human clinical trial, adult patients (average 53.3 years old) with acute ischaemic stroke received 2,000 FU nattokinase NSK-SD® 3 times (total 6,000 FU) a day at 8-hour interval for 7 days. Besides, during these 7 days, 0.4ml low molecular weight heparin (anti-factor Xa, 3,800 IU) 2 times a day by hypodermic injection and low-dose aspirin (150 – 325mg) or clopidogrel were also administered. Heparin (anticoagulant drug), aspirin and clopidogrel (anti-platelet drugs) are blood thinners. All patients were hospitalized within 6 hours of stroke occurrence and the treatment was administered after hospitalization. The overall efficacy data suggests that nattokinase does not lead to progression of underlying stroke. Instead, the combined intake is suggested to enhance fibrinolysis (breaking down of blood clots) and the beneficial effects on stroke patients were observed.
Study 2: In another human clinical trial, patients with cardiovascular disease (CVD) who were taking warfarin potassium tablets at a maintenance dose (1.5 < PT-INR < 3.0) received 2 doses of 1,700 FU nattokinase NSK-SD® after breakfast and dinner per day (3,4000 FU/day) or placebo for 6 months. Some of these patients showed improvement in clinical symptoms (i.e. shortness of breath, cold hands and feet) and biochemical profiles, including activated partial thromboplastin time (aPTT), prothrombin time (PT), D-dimer and plasmin inhibitor complex (PIC). No side effects were observed in all patients taking nattokinase. This study suggests that proper use of nattokinase is safe and effective for CVD patients who are taking warfarin.
✓ Support healthy immunity
In a randomised, double-blind, placebo-controlled clinical trial, 10 healthy males (average age 30.2) were orally administered a single-dose of 4,000 FU nattokinase NSK-SD® or placebo. Their blood samples were then collected at 6 hours following administration for analysis of natural killer (NK) cell activity. NK cells are a type of immune cells necessary in the early immune response to fight against viral infections, especially through clearance of virus-infected cells. Based on the results, administration of single-dose of 4,000 FU nattokinase NSK-SD® enhanced the activity of NK cells. Besides, NSK-SD® group also showed an increase of body temperature. As the subjects are healthy individuals, there was no change in blood pressure.
✓ Effects of NSK-SD® on peripheral skin temperature recovery after cold exposure
In a randomized, placebo-controlled clinical trial, healthy adult men received a single oral dose of either 2,000 FU NSK-SD® nattokinase or placebo. Two hours after administration, participants immersed both hands in 10°C water for one minute to induce temporary cooling.
Following cold-water immersion, the skin temperatures of the middle finger, palm, and back of the right hand decreased in all participants. However, temperature recovery was significantly faster in those who received NSK-SD® compared to the placebo group.
Importantly, acute administration of 2,000 FU NSK-SD® had no observable effect on heart rate, cardiac output, or sympathetic nervous system activity compared with placebo, demonstrating good tolerability.
These findings suggest that NSK-SD® may support healthy circulation and temperature regulation following exposure to cold conditions.
✓ Nattokinase NSK-SD® shown to support vascular health and recovery
In this clinical trial, adults of both sexes aged 18 and above, with various vascular health conditions and no prior exposure to pharmacological treatments such as anticoagulants or antiplatelets, were divided into three groups.
• Group 1 included individuals with venous concerns and received subcutaneous fondaparinux (7.5 mg/day) for 30 days, followed by oral nattokinase NSK-SD® (2,000 FU/day) for another 30 days.
• Group 2 consisted of individuals with superficial vein conditions who received enoxaparin (6,000 IU/day) subcutaneously for 30 days, then NSK-SD® (2,000 FU/day) for 30 days.
• Group 3 involved individuals recovering from venous surgery, who began NSK-SD® (2,000 FU/day) one day post-operation and continued for 30 days.
Across all groups, participants reported improvements in circulatory comfort indicators, and no adverse interactions or safety issues were observed. Notably, during the follow-up period, no new vascular events were recorded.
These findings support the potential of NSK-SD® to contribute to vascular health maintenance and circulatory support.
Research-Proven Health Benefits of Elastin F:
✓ Support healthy & flexible blood vessels
In a human clinical trial, healthy subjects (average age of 45.8) were orally administered 75mg Elastin F daily for 16 weeks and their pulse wave velocity was measured every 4 weeks to determine the ageing and stiffness of blood vessels. Supplementation with Elastin F significantly reduced vascular ageing and improved resilience of blood vessels.
✓ Support clear blood vessels
In an in vitro study, platelet-rich plasma was incubated with elastin peptide from bonito (Elastin F), elastin polypeptide from bonito and elastin peptide from bovine. Elastin F showed the highest inhibitory activity on platelet aggregation. This suggests that Elastin F could reduce formation of harmful clots in blood vessels and lower the risk of cardiovascular diseases.
✓ Support skin health
Study 1: In a double-blind trial, Japanese women in their 30s were orally administered 100mg Elastin F (+ 1000mg collagen + 30mg hyaluronic acid + 100mg chondroitin sulfate) or
placebo (1000mg collagen + 30mg hyaluronic acid + 100mg chondroitin sulfate) daily for 8 weeks. Addition of Elastin F to basic skin-care regimen resulted in significant improvement in skin suppleness, texture and reduction in wrinkles.
Subjective evaluation showed improvements in fine lines, dry face, smoothness and lasting duration of make-up.
Study 2: Fibroblasts are cells within the dermis layer of human skin that produces elastin and collagen. In this study, different concentrations of Elastin F were added to human skin fibroblast culture medium. Elastin F was found to help improve structural integrity and function of skin dermis, which are important for maintaining skin firmness and elasticity.
✓ Support joint health
In a double-blind trial, subjects were given placebo, 75mg Elastin F or 75mg Elastin F + glucosamine daily for 12 weeks and improvements were monitored using Visual Analogue Scale (VAS). Remarkable reduction in knee pain was observed in both Elastin F groups but not the placebo group. This suggests the synergistic effect between Elastin F and glucosamine in reducing knee pain.
Nattokinase NSK-SD® supports healthy aging at the cellular level, or, helps reduce the formation of Advanced Glycation End Products (AGEs)
Patented function: Supports the regulation of Advanced Glycation End Product (AGE) formation (Japanese Patent No. 7804957)
As we age, supporting metabolic balance becomes an important part of overall wellness. Advanced Glycation End Products (AGEs), which are linked to the aging process, are substances that form naturally when sugars interact with proteins or fats in the body. Over time, these substances accumulate and damage cells, which are associated with normal aging processes and may affect cellular function over time. This buildup is associated with natural aging processes and may influence overall metabolic health. such as damage to blood vessels and organs. By reducing the formation of AGEs, it may be possible to slow cellular aging and help maintain normal blood sugar levels and its related health problems.
In this study, streptozotocin (STZ)-induced diabetic rats were maintained on a basic diet as a control, a low-NK (nattokinase) diet (0.2 mg NK/g diet), or a high-NK diet (0.6 mg NK/g diet) for 14 days. NSK-SD as the source of NK. High-dose NK significantly inhibited glycogen deposition in the renal tubules, suggesting a supportive effect on normal physiological function. The AGE (Advanced Glycation End Products) level in the control group with induced diabetes was significantly higher than in the Sham group without diabetes. AGE levels were reduced in a dose-dependent manner in the NK groups, with the high-NK group showing the most significant reduction. Furthermore, compared with the control group, rats treated with the high-NK diet showed a significant suppression of the increase in circulating CRP levels on day 7, suggesting a role in supporting normal immune response. These findings indicate that NK suppresses glycogen deposition in renal tubules in a dose-dependent manner through mechanisms associated with the regulation of AGE formation under elevated glucose conditions in STZ-induced diabetic rats. Since AGEs contribute to aging and diabetic complications, NK’s inhibition of AGE formation highlights its potential role as an ingredient that supports general health and healthy aging.
Common Remedies for Circulatory Health in the Market
1) Blood Thinners (Medications)
Blood thinners are prescribed medicines that prevent blood clots from forming. They also keep existing blood clots from getting larger. There are 2 main types of blood thinners –
anticoagulants and antiplatelet drugs.
• Anticoagulants slows down the body’s process of making clots.
• Antiplatelet drugs prevents platelets from clumping together to form a clot.
However, blood thinners may cause side effects in some people. Serious bleeding is the most common reaction - heavy periods, bleeding gums, prolonged
bleeding from a cut, etc. Other possible side effects include dizziness, muscle weakness, hair loss or rashes. Besides, the presence of blood thinners in body system can increase the risk of internal bleeding after an injury, even if external bleeding did not occur.
2) Supplements
Although there are many types of Nattokinase available in the market, did you know that nattokinase activity may decrease when mixed with certain foods/ingredients such as red yeast rice (Monascus ruber-fermented rice), black vinegar, apple vinegar and vitamin C. Please note that the efficacy of nattokinase NSK-SD® will not be affected by the presence of Elastin F in VesseCLEAR EX.
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Did you know that natto is also linked to longevity? (Biosci Biotechnol Biochem 77(2): 392-394 (2013)). |
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The presence of lipofuscin in the skin is associated with the appearance of pigmentation commonly known as liver spots.
Healthy Blood Vessels, Healthy Living
Restore your everyday peace of mind with LABO Nutrition VesseCLEAR EX. Formulated to perform 4 core health functions to keep your cardiovascular system running smoothly and naturally.
- Clean Blood Vessels: Dissolves web-like fibrin clots naturally
- Supple & Flexible Arteries: Restores natural elasticity to stiffening blood vessels
- Smooth Blood Flow: Promotes steady circulation throughout the entire body
- Healthy Blood Pressure: Supports optimal pressure and cardiovascular ease
The Cardiovascular Champion
Recognised by healthcare partners and trusted by thousands of families every day.
What Customers Are Saying
Real, individual experiences from people who use VesseCLEAR EX daily.
"Product is amazing!! I am overweight, overworked, and don't eat properly. 53 and haven't felt this good in 15 years. I subscribed after the first night."
"I'm now on my 2nd order and plan to keep using it. I felt comfortable taking vesseclear."
"Absolutely could feel this working within 90 mins of taking it. Felt "the tingle" in the legs and top of chest, that was how I knew it was working. This is the first Nattokinase I could feel!"
"Works well in supporting my circulation & overall vascular health."
"My hands and feet felt warmer, and over time, my face look rosier."
Smooth Circulation, Stronger You
Designed to address key cardiovascular functions that decline as we age, providing daily support where your body needs it most.
1. Clear Blood Vessels
Supports healthy blood vessel function and helps maintain normal blood circulation throughout the body.
2. Flexible & Youthful Arteries
Helps maintain healthy artery function and supports normal blood vessel flexibility.
3. Smooth Blood Flow
Supports healthy blood circulation and the normal transport of oxygen and nutrients throughout the body.
4. Healthy Blood Pressure
Helps maintain healthy blood pressure levels and supports normal cardiovascular function.
Dangers of Poor Circulation & Aging Arteries
Unchecked arterial stiffness and fibrin buildup can lead to serious hidden health risks throughout the body.
1. Silent Health Risks
Poor blood circulation can affect vital organs throughout the body:
- Brain: Stroke
- Heart: Heart Attack
- Leg: Deep Vein Thrombosis (DVT)
2. Arterial Stiffness Increases With Age
Arterial stiffness increases significantly in your 30s and 40s. Heart risks double (50%) even in healthy adults as arteries lose their flexibility.
3. Unclog Arteries & Protect Peace of Mind
In an unhealthy blood vessel, fibrin clot doesn't break down, leading to a clogged artery. In a healthy blood vessel, fibrin dissolves naturally to maintain a normal artery.
2 Proven Ingredients for Confident, Active Living
A powerful synergy combining Japan's premier Nattokinase and high-absorption Elastin F.
No. 1 Most Researched Nattokinase NSK-SD®
Extracted from fermented soybeans (natto), Nattokinase NSK-SD® dissolves web-like fibrin formed in blood vessels to promote smooth flow.
- Fast absorption within 14 hours
- Works in harmony with the body without interfering with wound healing or normal clot formation
Elastin F (Elastin Peptide from Fish)
Essential protein extracted from fish to restore resilient, elastic arteries and support total body flexibility.
- Stays active and stable to support flexible blood vessels
- Low-molecular-weight peptides for maximum body absorption
NSK-SD® in Action
Nattokinase NSK-SD® helps dissolve web-like fibrin formed in the blood vessels without disrupting normal blood clotting balance.
Supports fibrin management
Studied for its role in supporting the body’s natural fibrin-management processes — fibrin being the protein involved in normal clot formation and clearance.
Works with your own system
Also studied for helping the body’s own balancing enzymes work more freely — a gentle, self-regulating effect that supports normal circulation rather than overriding it.
See how Nattokinase NSK-SD® Breaks Down Blood Clots
Watch laboratory demonstrations showing the natural clot-dissolving action of Nattokinase NSK-SD® in real time.
NSK-SD® Fibrin Dissolution Test
Thrombus Breakdown in Action
Bounce Back with Elastin Support
Elastin F provides critical elastic support across multiple organ systems:
- Supports artery flexibility & resilience
- Promotes healthy blood flow
- Maintains skin firmness & elasticity
- Supports lung & organ flexibility
Why Elastin F Matters?
Your body produces very little to no new elastin after Age 20. Nearly 50% of the body's total elastin is found in the aorta — the largest artery.
Without Enough Elastin:
• Arteries stiffen — your heart works harder
• Skin becomes saggy and less firm
• Organs lose flexibility and function less efficiently
Elastin F Advantage:
• 1000 times more flexible than collagen
• Supported by extensive safety studies
• Highly resistant to heat and acidic conditions
The Clean & Real Nattokinase Standard
Enjoy all the functional benefits of authentic Nattokinase NSK-SD® — purified to remove unwanted compounds while delivering maximum, clinically proven cardiovascular support.
NO Vitamin K2
Specifically extracted out to ensure seamless compatibility with blood-thinning medication guidelines (such as Warfarin) and prevent clotting risks.
NO Purines
Purified using advanced patented technology to safeguard joint comfort and prevent unwanted uric acid buildup.
NO Pungent Natto Taste or Smell
Encapsulated in small, smooth vegetable capsules for effortless, odorless daily consumption.
Choose Real Nattokinase
See why authentic NSK-SD® outperforms generic nattokinase supplements on the market.
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VesseCLEAR EX
2000 FU |
Other nattokinase products | |
|---|---|---|
| Original, Branded NSK-SD® | ||
| Clinically Proven | >56 studies* | |
| Acid-Resistant DRcaps® | ||
| Health Benefits |
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Take REAL Nattokinase - NSK-SD®.
NO NSK-SD® = FAKE Nattokinase
*Based on the number of research studies on NSK-SD® as of June 2026
Which VesseCLEAR is Right for You?
Compare our complete vascular health series to find the exact formula tailored to your functional needs.
| HEALTH NEED | VesseCLEAR EX Daily Maintenance |
ULTIMATE VesseCLEAR EX High Strength |
VesseCLEAR CX Holistic Wellness / Vegan |
|---|---|---|---|
| Product Showcase |
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| Primary Focus | Essential Circulation Support | Strong Circulation Support | Circulation, Cholesterol & Total Wellness |
| Nattokinase Strength | 2000 FU | 4000 FU | 2000 FU |
| Blood Circulation |
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| Blood Vessel Flexibility | (Elastin F) |
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| Blood Pressure Support |
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| Cholesterol Support | - | - | |
| Alert Immune Response | - | - | |
| Brain Health |
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| Joint Health | - | ||
| Gut Health & Mood Support | - | - | |
| Vegan-Friendly | - | - | (60 Vegan Caps) |
| View More | View More | View More |
Usage & Dosage Guidelines
Follow these guidelines for both everyday maintenance and serious circulatory support.
Supplement Facts
VesseCLEAR EX
OR
1 capsule, 3 times daily every 8 hours.
Frequently Asked Questions
Everything you need to know about VesseCLEAR EX
Q1: How does VesseCLEAR EX differ from VesseCLEAR?
VesseCLEAR EX is an upgraded formula that adds premium Elastin F to the pure nattokinase NSK-SD® found in the original.
Elastin F is a readily absorbable peptide extracted from bonito fish that helps support elastic and supple blood vessels.
Q2: What is Nattokinase NSK-SD®?
Nattokinase NSK-SD® is a proprietary enzyme extracted from traditional natto that is clinically proven to dissolve fibrin and break down blood clots.
It is developed by world leader JBSL using a patented process to result in high purity, maximal bioavailability, and non-GMO stability.
Q3: What is Elastin?
Elastin is a highly flexible protein essential for the resilience of arteries, skin, and cartilage.
It helps arteries maintain constant pressure despite pulsating blood flow, though it naturally degenerates with age, increasing the risk of heart failure.
Q4: Does VesseCLEAR EX Nattokinase NSK-SD® contain vitamin K2?
No, vitamin K2 is specifically removed during production to prevent interference with blood-thinning medications like Warfarin.
Because natto is naturally rich in K2—which can increase clotting—removing it eliminates potential adverse drug interactions.
