US studies have found that the liver will use a specific protein to metabolize the fat in the abdomen. When this protein in the liver is depleted, it will extract the protein in brain to carry out fat metabolism, leading brain degradation and reduce memory. This means that the bigger the "belly", it will consume more brain protein for metabolism, more damage to the brain. Another study also show obese men and women are estimated to be about 35% more likely to develop Alzheimer's disease compared to people of a normal weight.