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Research Proven Health Benefits:
The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.
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Supports the body to cope with stress
Study 1: In this clinical trial, subjects with a history of stress problems were orally administered 300 mg of KSM-66® Ashwagandha Extract or placebo twice a day for a period of 60 days. Compared to placebo group, group treated with KSM-66® Ashwagandha Extract showed a significant reduction in scores on all the stress-assessment scales and serum cortisol levels on day-60. These findings suggest KSM-66® Ashwagandha Extract helps support the body's response to stress, which results in better quality of life.
Study 2: Stress has been linked to various conditions, including obesity. In this clinical trial, 52 subjects were given 300 mg of KSM® Ashwagandha Extract or a placebo twice daily for 8 weeks. The group taking KSM® Ashwagandha Extract showed improvements in managing stress, food cravings, serum cortisol levels, body weight, and body mass index, along with increased self-reported happiness, compared to the placebo group. These findings suggest that KSM® Ashwagandha Extract may support body weight management in adults experiencing stress.
Study 3: In this clinical trial, 64 adults experiencing stress were given KSM-66® Ashwagandha Extract or a placebo to assess its safety and potential benefits in managing stress, anxiety, and overall well-being. Participants took 300 mg of KSM-66® Ashwagandha Extract or placebo twice daily for 60 days. Compared to the placebo group, the KSM-66® Ashwagandha Extract group showed a significant reduction (p<0.0001) in stress-assessment scores and lower serum cortisol levels (p=0.0006) on day 60. These findings suggest that KSM-66® Ashwagandha Extract may support stress management and contribute to overall well-being. (Indian J Psychol Med. 34(3): 255-262 (2012)).
Study 4: In this clinical trial, 64 adults with stress were given 300 mg of KSM-66® Ashwagandha Extract or a placebo twice daily for 60 days. The effectiveness of KSM-66® Ashwagandha Extract in supporting healthy cortisol (stress hormone) levels was assessed on day 60. The results showed a 27.9% reduction in cortisol levels from baseline in the KSM-66® Ashwagandha Extract group, compared to a 7.9% reduction in the placebo group. The difference in cortisol reduction between the two groups was statistically significant (p = 0.002), suggesting that KSM-66® Ashwagandha Extract may help promote healthy cortisol levels.
Support emotional health
In this clinical trial, healthy adults aged 18 to 54 years old with subclinical feelings of low mood and anxiety and/or stress were orally administered 30 mg standardised saffron extract or placebo for 8 weeks. At the end of study, participants who administered with saffron extract reported reduced depression scores and improved social relationships. Besides, saffron supplementation resulted in significant increase in urinary crocetin levels, which is believed to reduce oxidative stress. Besides, saffron extract administration also attenuated typical stress-induced decrease in heart rate variability (HRV) (as the heart rate is consistently high) during exposure to stressor. These findings suggest that saffron extract may support improvements in subclinical depressive symptoms and resilience to stress.
Mitigate obsessive-compulsive disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric disorder in which a person experiences obsessive thoughts and repetitive compulsive actions. In this study, OCD-like behaviour (excessive self-grooming) was induced in rats by mCPP. Administration of crocins, an active compound in saffron plants, attenuated mCPP-induced excessive self-grooming. These findings suggest that saffron may help support the management of compulsive behaviors. (Neurosci Lett.528(1):27-30 (2012)).
Improve sleep quality
Study 1: In this clinical trial, stressed healthy adults with a baseline perceived stress scale (PSS) score > 20 were orally administered 125 mg KSM-66® Ashwagandha Extract, 300 mg KSM-66® Ashwagandha Extract or placebo twice daily for 8 weeks. Stress was assessed using PSS, while anxiety was assessed using the Hamilton-Anxiety (HAM-A) scale. Sleep quality was assessed using a seven-point sleep scale. Results showed that the groups administered with 250 mg/day Ashwagandha and 600 mg/day Ashwagandha showed a significant reduction in PSS scores and serum cortisol levels and improvement in sleep quality. These findings suggest the potential use of KSM® Ashwagandha Extract in improving sleep quality in those with stress and anxiety.
Study 2: In this clinical trial, elderly aged between 65 to 80 years were orally administered 300 mg KSM-66® Ashwagandha Extract or placebo twice daily for 12 weeks. Compared to placebo group, there were significant improvement in WHOQOL-BREF (quality of life), sleep quality and mental alertness. These findings suggest the efficacy of KSM-66® in improving general well-being and sleep quality of elderly.
Study 3: In this clinical trial, the subjects with mild to moderate sleep disorder associated with anxiety wee orally administered saffron extract (15.5 mg/day) or placebo (maltodextrin) for 6 weeks. Their sleep quality was assessed using actigraphy, LSEQ and PSQI questionnaires. Results showed that 6-week saffron supplementation led to an increased time in bed assessed by actigraphy, improved ease of getting to sleep assessed by LSEQ questionnaire and improved sleep quality, sleep latency, sleep duration and global scores assessed by the PSQI questionnaire. A lower PSQI scores indicate better sleep quality. Meanwhile, those parameters were not modified by placebo. These findings suggest saffron extract could be a safe and natural nutritional approach to improve sleep quality and duration.
Help support the relief of premenstrual syndrome (PMS) symptoms
In this clinical trial, women aged 20 to 45 years with regular menstrual cycles and experience of symptoms of premenstrual syndrome (PMS) for at least 6 months were orally administered 30 mg/day saffron (15 mg twice daily) or placebo (twice a day) for two menstrual cycles (cycles 3 and 4). Results showed that saffron (Crocus sativus) was effective in relieving the symptoms of PMS. Compared to placebo, there was significant improvement in cycles 3 and 4 in the Total Premenstrual Daily Symptoms (to assess PMS severity) and Hamilton Depression Rating Scale (to determine severity of depression). These findings suggest the efficacy of saffron in relieving the symptoms of PMS.
Helps relieve perimenopausal symptoms
Perimenopause is the period of a woman’s life shortly before menopause, which is commonly associated with climacteric symptoms.
In this clinical trial, perimenopausal women with climacteric symptoms were orally administered 300 mg KSM-66® Ashwagandha Extract or placebo twice daily. Compared to placebo, administration of KSM-66® Ashwagandha Extract resulted in a significant reduction in total MRS (menopause rating scale), reflected by significant reductions in the psychological, somato-vegetative, and urogenital domains. Besides, administration of KSM-66® Ashwagandha Extract demonstrated a statistically significant reduction in total MENQoL (menopause-specific QoL) scores, indicating an improvement in quality of life. These findings suggest the efficacy of KSM-66® Ashwagandha Extract in relieving mild to moderate climacteric symptoms in perimenopause in women (J Obstet Gynaecol Res. 47(12): 4414-4425 (2021)).
Supports Sexual Function
Study 1: In this clinical trial, 50 females were orally administered 300 mg KSM-66® Ashwagandha Extract or placebo for 8 weeks. Two psychometric scales, which are Female Sexual Function Index (FSFI) Questionnaire and Female Sexual Distress Scale (FSDS), as well as the number of total and successful sexual encounters were used to assess the sexual function. Compared to placebo, group administered with KSM-66® Ashwagandha Extract observed significant improvement in the FSFI Total score, FSFI domain scores for ‘arousal’, ‘satisfaction’, ‘lubrication’, and ‘orgasm’. The KSM-66® Ashwagandha Extract also showed significant improvement in the FSDS score, and had a greater number of successful sexual encounters at the end of the study. These findings suggest that the females’ sexual function can be improved via the oral administration of KSM-66® Ashwagandha Extract.
Study 2: In this clinical trial, married male patients with significant mood challenges who were stabilized on a commonly prescribed medication and reported sexual impairment were given saffron (15 mg twice per day) or a placebo for 4 weeks. Sexual function was assessed using the International Index of Erectile Function (IIEF) scale at baseline, week 2, and week 4. The results indicated that the saffron group experienced greater improvements in the erectile function and intercourse satisfaction domains, as well as in total scores, by week 4 compared to the placebo group. Additionally, 60% of patients in the saffron group achieved normal erectile function (score > 25 on the erectile function domain) at the end of the study, compared to 7% in the placebo group. These findings suggest that saffron may help support improvements in erectile function for individuals experiencing sexual concerns related to their treatment.
Study 3: In this clinical trial, women with major mood challenges who were stabilized on a commonly prescribed medication for at least 6 weeks and reported feelings of sexual dysfunction were given saffron (30 mg daily) or a placebo for 4 weeks. The Female Sexual Function Index (FSFI) was assessed at baseline, week 2, and week 4. At the end of the study, patients in the saffron group showed greater improvements in the total FSFI score, as well as in the arousal, lubrication, and pain domains compared to the placebo group. These findings suggest that saffron may help support the management of some sexual concerns related to their treatment in women.
Support Male Fertility
Study 1: In this clinical trial, male patients with low sperm count (defined as fewer than 20 million sperm per mL of semen) were given 225 mg of KSM-66® Ashwagandha Extract or a placebo three times daily for 90 days. The results indicated a 167% increase in sperm count, a 53% increase in semen volume, and a 57% increase in sperm motility by day 90 compared to baseline in the group receiving KSM-66® Ashwagandha Extract. The placebo group showed minimal improvement in these parameters. Additionally, there were significantly greater improvements and regulation in serum hormone levels in the group receiving KSM-66® Ashwagandha Extract compared to the placebo group. These findings suggest that KSM-66® Ashwagandha Extract may help support the management of low sperm count.
Study 2: In a study, 60 men with normal sperm levels who were experiencing infertility were given Ashwagandha root powder for 3 months. The general semen characteristics were assessed before and after the treatment. Ashwagandha was found to significantly enhance all the semen parameters. In men with psychological stress, there was a 36% increase in sperm concentration and a 13% increase in sperm motility. The pregnancy outcome for men under stress who were treated with Ashwagandha showed a 15% success rate. These findings suggest that Ashwagandha may help support fertility in men experiencing stress-related challenges.
Study 3: In this clinical trial, male patients with erectile difficulties were given a tablet containing 200 mg of saffron every morning for 10 days. Patients underwent the nocturnal penile tumescence (NPT) test and completed the International Index of Erectile Function (IIEF-15) questionnaire at the start of the treatment and after 10 days. After the saffron administration, there was a notable improvement in tip rigidity, tip tumescence, base rigidity, and base tumescence. Compared to baseline, the IIEF-15 total scores were significantly higher following saffron treatment. These findings suggest that saffron may help support sexual function in patients with erectile difficulties, potentially leading to an increased number and duration of erectile events.
Study 4: In this clinical trial, nonsmoker men with unexplained difficulty in achieving conception were given saffron for 3 months. Each week, 50 mg of saffron was dissolved in drinking milk and administered three times a week. Semen analysis was conducted before and after the treatment. The results showed a significant increase in the percentage of sperm with normal morphology and improved sperm motility following saffron administration. These findings suggest that saffron may help support sperm health in men experiencing challenges in conception.
Improve exercise performance
Study 1: In this clinical trial, healthy athletic adults orally administered 300 mg KSM-66® Ashwagandha Extract or placebo twice daily. Their cardiorespiratory endurance measured using the oxygen consumption at peak physical exertion (VO2 max) levels during a 20 m shuttle run test, as well as quality of life (QOL) was assessed. Compared to placebo, there was greater increase from baseline (P < 0.0001) in the mean VO2 max with KSM-66® Ashwagandha Extract at both 8 weeks and 12 weeks. Besides, the QQL for all subdomains significantly improved to a greater extent in the Ashwagandha group at 12 weeks compared to placebo. These findings suggest the efficacy of KSM-66® Ashwagandha Extract in enhancing the cardiorespiratory endurance and improves QOL in healthy athletic adults (Ayu. 36(1): 63-68 (2015)).
Study 2: In this clinical trial, young male subjects (18–50 years old) with little experience in resistance training were orally administered 300 mg of KSM-66® Ashwagandha Extract or placebo twice daily for 8 weeks. Compared to placebo, KSM-66® Ashwagandha Extract group had significantly greater increases in muscle strength on the bench-press exercise and the leg-extension exercise, as well as significantly greater muscle size increase at the arms and chest. Besides, KSM-66® Ashwagandha Extract group had significantly greater reduction of exercise-induced muscle damage as indicated by the stabilization of serum creatine kinase, significantly greater increase in testosterone level, and a significantly greater decrease in body fat percentage. These findings suggest the beneficial effects of KSM-66® Ashwagandha Extract in increasing muscle mass and strength, and it may be especially useful in conjunction with a resistance training program.
Supports healthy inflammatory responses
In this study, mice and rats were given saffron extract through intraperitoneal injection to evaluate its potential discomfort-relieving (antinociceptive) effects and ability to support a healthy inflammatory response. The saffron extract demonstrated activity against discomfort induced by acetic acid and showed an effect on acute inflammation as assessed by xylene-induced ear swelling in mice, as well as chronic inflammation measured through formalin-induced swelling in the rat paw. The study also included diclofenac, a medication commonly used to reduce discomfort and swelling, for comparison. These findings suggest that saffron extract may have potential discomfort-relieving properties and support a healthy inflammatory response.
Support metabolic health
Study 1: In this clinical trial, patients with elevated blood sugar levels, averaging 54.1 years of age, were given saffron tablets (100 mg/day) or a placebo for 12 weeks. Compared to placebo, saffron supplementation resulted in significant decreases in waist circumference and malondialdehyde (MDA), a marker of oxidative stress. These findings suggest the metabolic health benefits of saffron.
Study 2: In this clinical trial, 40 patients with at least two abnormalities in high-density lipoproteins (HDL) ≤ 40, low-density lipoproteins (LDL) ≥ 130, triglycerides (TG) ≥ 200, total cholesterol (Cho) ≥ 200 were orally administered saffron or placebo. Compared to baseline, saffron administration resulted in significant reduction in TG, Cho and LDL. Compared to placebo, there was significant decrease in TG, Cho and LDL in the saffron group. These findings suggest that saffron may have potential benefits for supporting lipid profiles in patients with lipid abnormalities.
Study 3: In this clinical trial, patients with elevated blood sugar levels were given 100 mg/day of saffron or a placebo for 8 weeks, with fasting blood samples collected at baseline and the end of the intervention. Compared to the placebo group, saffron supplementation resulted in notable decreases in fasting blood glucose levels and inflammatory markers TNF-α and IL-10. These findings suggest that saffron may help support healthy blood glucose levels and a healthy inflammatory response in individuals with elevated blood sugar.
Study 4: In this clinical trial, overweight and obese individuals with elevated blood sugar levels were given saffron (15 mg/day) or a placebo for 8 weeks. Compared to baseline, saffron supplementation resulted in notable decreases in fasting blood sugar and glycosylated hemoglobin (HbA1c), which reflects average blood sugar levels over the last 2 to 3 months. Additionally, compared to the placebo group, saffron was associated with significant reductions in fasting blood sugar and HbA1c, along with an increase in DPPH radical scavenging activity. These findings suggest that saffron supplementation may help support glycemic and antioxidant status in overweight and obese individuals with elevated blood sugar levels.
When the body is under stress, the adrenal glands trigger the release of glucose stored in various organs, which often leads to elevated levels of glucose in the bloodstream. During stressful situations, the insulin levels drop and stress hormone levels go up. That makes it harder for the insulin to work the way it should. All of this may raise the blood glucose levels.
Study 5: In this in vitro study, cellular models were used to assess the potential effects of Ashwagandha root extract on glucose uptake. Differentiated myotubes and matured adipocytes were treated with increasing concentrations of the extract. After 4 hours of incubation with a glucose analog, fluorescence measurements were taken to evaluate glucose uptake. The results indicated that Ashwagandha root extract increased glucose uptake in myotubes by 35% and in adipocytes by 22%. These findings suggest that Ashwagandha root extract may help support healthy blood glucose levels.
Study 6: In this study, rats with elevated cholesterol levels were given Ashwagandha root powder as part of their diet. The results showed a notable reduction in total lipids in the group receiving Ashwagandha. Additionally, there was a significant decrease in blood cholesterol and triglycerides, along with an increase in HDL-cholesterol levels. Compared to normal rats, those receiving Ashwagandha also exhibited a reduction in lipid peroxidation. These findings suggest that Ashwagandha root powder may support healthy blood lipid levels.
Study 7: In this study, male rats were fed a high-fat diet for 10 weeks, and then saffron extract was orally administered at 80 mg/kg body weight daily for 3 weeks. Saffron extracts significant decreased serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in obese rats, while increased the serum high-density lipoprotein cholesterol (HDL-C). Meanwhile, atherosclerosis-index (LDL/HDL), atherogenic index (TC/HDL) and the liver enzymes (ALT, AST and ALP) were also significantly reduced. Besides, saffron extract significantly decreased the homeostasis model assessment-estimated insulin resistance index (HOMA-IR), indicating its potential cardioprotective effects and increased antioxidant capacity (FRAP). These findings indicate the potential of saffron extract in supporting healthy lipid levels and reducing insulin resistance.
Support cognitive function
Study 1: In this clinical trial, 50 adults with mild cognitive challenges were orally administered 300 mg KSM-66® Ashwagandha Extract or placebo daily for 8 weeks. Compared to placebo, administration of KSM-66® Ashwagandha Extract resulted in a significant improvement in both immediate and general memory after 8 weeks, as evaluated using the Wechsler Memory Scale III subtest scores. Besides, group administered with KSM-66® Ashwagandha Extract also demonstrated a significantly greater improvement in the executive function, sustained attention and information-processing speed using the scores on the Eriksen Flanker task, Wisconsin Card Sort test, Trail-Making test part A, and the Mackworth Clock test. These findings suggest that KSM-66® Ashwagandha Extract may help support memory and cognitive functions in adults with mild cognitive challenges. (J Diet Suppl. 14(6): 599-612 (2017)).
Study 2: In this clinical trial, patients with memory loss and mild cognitive changes were orally administered saffron for 12 months. Results showed that patients who received saffron had improved Mini-Mental State Examination (MMSE) scores, while the control group experienced deterioration. MMSE is commonly used as a screening test for cognitive function. Additionally, magnetic resonance imaging (MRI), electroencephalogram (EEG), and event-related potential (ERP) assessments indicated improvements in specific cognitive domains. These findings suggest the beneficial effect of saffron in managing mild cognitive changes.
Study 3: In this clinical trial, patients with early-stage cognitive decline were orally administered 30 mg/day of saffron or a placebo for 16 weeks, during which their cognitive profiles were monitored. Compared to the placebo group, the saffron group showed improved cognitive function over the 16-week period. Specifically, patients taking saffron had lower scores on the ADAS-Cog (Alzheimer's Disease Assessment Scale-Cognitive Subscale) and CDR-SB (Clinical Dementia Rating Scale-Sums of Boxes), indicating better cognitive performance. There were no significant differences in adverse events between the saffron and placebo groups. These findings suggest that saffron may be a safe and effective option for supporting cognitive function in individuals with early-stage cognitive decline.
Supports thyroid health
In this clinical trial, patients with slightly elevated thyroid-stimulating hormone (TSH) levels (4.5-10 μIU/L) were orally administered 300 mg of KSM-66® Ashwagandha Extract or a placebo twice daily for 8 weeks. Compared to the placebo group, those taking KSM-66® Ashwagandha Extract showed significant improvements in serum TSH, triiodothyronine (T3), and thyroxine (T4) levels. Furthermore, the administration of KSM-66® Ashwagandha Extract effectively helped normalize thyroid indices during the 8-week treatment period. These findings suggest the potential benefits of KSM-66® Ashwagandha Extract for supporting healthy thyroid function in individuals with elevated TSH levels. (J Altern Complement Med. 24(3): 243-248 (2018)).
Support healthy vision
Study 1: In this clinical trial, patients with wet or dry eye conditions were orally administered 30 mg/day saffron or placebo for 6 months. At 3 months after saffron administration, there was a significant increase in electroretinography (ERG) results (p = 0.027), which measures the electrical response of the light-sensitive cells in the eyes. At the follow-up, patients with wet eye conditions administered saffron showed a significant decrease in optical coherence tomography (OCT) results, which is used for early diagnosis of various serious eye conditions. These findings suggest saffron supplementation may help support retinal function in patients with these eye conditions.
Study 2: In this clinical trial, patients with early vision changes were orally administered 20 mg/day saffron or placebo for 3 months, followed by a switch to placebo or saffron for an additional 3 months. Focal electroretinograms (ERG), which measure the functional integrity of the central macula, were recorded after the 3-month supplementation period. Compared to placebo, saffron supplementation resulted in a significant increase in the amplitude of focal ERG. Additionally, focal ERG thresholds decreased after saffron supplementation, while no changes were observed in the placebo group. These findings suggest that saffron supplementation may help support retinal flicker sensitivity in individuals with early vision changes.
