Active ingredients per 2 capsules: 100mg Boswellin® Super Boswellia serrata Extract, 500mg Curcumin C3 Complex® Turmeric Root Extract, 10mg BioPerine® Black Pepper Extract, 890mg OptiMSM®.
Unique properties of key ingredients
Boswellin® Super Boswellia Extract:
- Standardised to 30% AKBA
- Research proven safety and efficacy
- Kosher and Halal certified
- Patented in US, Europe and globally, pertaining to specific applications of boswellic acids
Curcumin C3 Complex®
- Standardised to ≥ 95% curcuminoids
- Highly safe. The only curcumin in the market that has been reviewed and acknowledged by the USFDA for its GRAS (Generally Recognised As Safe) status
- Research proven. More than 20 years of research; more than 80 research papers including 45+ clinical studies have been published; granted “Most Extensively Studied and Clinically Documented” status
- Numerous awards. Received “Scientific Achievement Award” in 2007 and “Product Merit Award” in 2008 from Nutrition Business Journal; “Functional Ingredients Editor’s Choice Award (Marketing)” in 2012; “The Most Trusted Brand” for over 2 decades
- Kosher and Halal certified.
- Patented in US and Europe, pertaining to “Bioprotectant” composition of three curcuminoids
BioPerine® Black Pepper Extract:
- Standardised to ≥ 95% piperine
- Highly safe. Granted GRAS status after a comprehensive review of safety and toxicology data by an independent panel of scientists with international repute.
- Research proven safety and efficacy
- Long-standing ingredient. Introduced in the marketplace since 2 decades ago to enhance bioavailability of other nutrients
- Kosher and Halal certified
- Patented in US, Europe, Japan and Canada
- Comprised of 34% bioavailable sulfur - the richest source known to man
- Highly safe. The only GRAS-designated MSM on the market. There is no known evidence of interactions between OptiMSM® and pharmaceuticals, herbs, vitamins or minerals.
- Research proven. Backed by numerous pre-clinical and clinical studies for safety and efficacy
- High quality. Non-GMO, gluten-free, allergen-free, non-shellfish-derived, no banned substances and vegan MSM backed by extensive toxicology data.
- High purity. A proprietary multi-stage distillation process ensures a 99.9% pure product to guarantee a consistent, high-quality form of MSM
- High consistency: 25+ years of manufacturing expertise backed by ISO 9001:2015 registration, FSSC22016 certification, HACCP and cGMP compliance
- Kosher and Halal certified
2 capsules daily after meal.
The bioavailability of various boswellic acids, especially AKBA was shown to be significantly enhanced by concomitant administration of a fat-containing meal (e.g. fried eggs, bacon, milk etc.)
Caution: Dietary supplements are not a substitute for a healthy diet. If you are pregnant, nursing or taking any medication, please consult your physician before consuming any supplements. Discontinue use 2 weeks before surgery.
Storage: Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
This product is not intended to diagnose, treat, cure or prevent any disease.
Q: How does FlexC MAX help relieve joint pain?
A: FlexC MAX is a vegetarian, extra strength & fast-acting formula made with curated patented bioactive extracts in functional dosage for maximum potency. Comprising natural ingredients of Boswellin® Super Boswellia serrata Extract, Curcumin C3 Complex® Turmeric Root Extract, BioPerine® Black Pepper Extract and OptiMSM®, their synergistic effects help support a healthy inflammatory response and antioxidant protection to help relieve joint discomfort, support natural tissue repair process and support healthy joint structures. Besides joint pain, FlexC MAX also provides fast relief from body discomfort and supports overall wellness.
Q: I always experience muscle and joint pain after each high-intensity training. Can FlexC MAX help relieve the pain quickly?
A: Yes, it can. Most people would experience pain relief within 3 days though the results may vary between individuals. Research shows that OptiMSM® - one of the active ingredients in FlexC MAX - is effective in reducing post-exercise muscle and joint pain.
Q: I do not have joint pain. Can I take FlexC MAX to maintain joint and overall body wellness?
A: Yes, you can. In addition to supporting joint comfort, FlexC MAX also nourishes damaged cartilage, tendon and ligaments in the joints to support self-healing, thereby maintaining healthy joint structures and range of motion. Besides joints, FlexC Max contains antioxidant which deters the accumulation of oxidative damage developed as a result of ageing and stress on the body. Since inflammation is associated with a wide range of health problems, the anti-inflammatory properties of FlexC MAX is beneficial in supporting overall body wellness. For general health maintenance, the suggested dosage is 1 capsule daily.
Q: What is extract standardisation and why is it important for a herbal supplement?
A: Extract standardisation is a quality marker to ensure the ingredients in a supplement are of the same quality and purity in every batch. A standardised extract has one or more bioactive compounds in a guaranteed amount and is usually listed in percentages. All 3 herbal ingredients in FlexC MAX – Bowellia, turmeric root and black pepper extracts are standardised and hence are guaranteed of consistent potency.
In contrast, unstandardised supplements may not yield consistent effects. If a product does not have a listed standardised percentage, then it could be occurring in any amount, including one that is too low to produce any effects. Besides, unstandardised supplements may pose risks of overdose or dangerous side effects.
Q: What is the difference between turmeric, curcumin and curcuminoids?
A: Turmeric is a bright yellow spice powder that derives from the root of a plant known as Curcuma longa. Curcuminoids are a family of active compounds within turmeric, this includes curcumin, demethoxycurcumin and bisdemethoxycurcumin. Curcumin is the primary and most-studied curcuminoid in turmeric which possesses anti-oxidative and anti-inflammatory properties.
Q: Curcumin is known to have low bioavailability. What is bioavailability and how to enhance the bioavailability of curcumin?
A: Bioavailability refers to the capability of a nutrient in having an active effect on the body after it has been introduced via blood circulation. The low bioavailability of curcumin is mainly caused by low water solubility, poor absorption by the body and rapid metabolism and excretion from the body.
Nonetheless, combining curcumin with piperine (major active component of black pepper) has shown to increase the bioavailability of curcumin by 20-fold, allowing it to provide multiple health benefits. Hence, the combined ingredients of Curcumin C3 Complex® turmeric root extract with BioPerine® black pepper extract in FlexC MAX are more readily available in the body.
Q: Can I take FlexC MAX alongside painkillers, medicines or NSAIDs?
A: Yes, you can. Please take FlexC MAX at least 2 hours apart from painkillers/NSAIDs to ensure the efficacy of FlexC Max is not compromised. A study showed that significantly higher numbers of subjects reporting decreased or no use of NSAID after taking Curcumin C3 Complex® (one of the key ingredients in FlexC MAX) (Phytother Res 28: 1625 – 1631 (2014)). Another study showed the combination of turmeric and boswellia extracts was more effective in reducing pain than NSAID (Mol Med Rep 8(5): 1542-1548 (2013)), this suggests the efficacy of FlexC MAX in managing joint discomforts.
Q: Is FlexC MAX safe for use during pregnancy and breastfeeding?
A: FlexC MAX has not been studied for use during pregnancy and breastfeeding. If you are pregnant or breastfeeding, we strongly advise you to consult your physician before taking any supplements.
Q: Is FlexC MAX safe to be taken for long-term?
A: Yes, it is safe. FlexC MAX is formulated with ingredients that have been proven safe and granted GRAS (Generally Recognised as Safe) status and thus, can be taken for long-term. If you have joint concerns or other ongoing health concerns, you are recommended to take 2 capsules of FlexC MAX daily for a minimum of 3 months to observe best results. Thereafter, you may want to reduce to 1 capsule daily for general maintenance. However, if you wish to continue with 2 capsules of FlexC MAX daily, you may do so as long as the desired health benefits are being experienced, which could be for long periods of time.
Q: When is the best time to take FlexC MAX?
A: FlexC MAX is best to be taken after meals, especially meals containing fats. Studies showed the bioavailability of AKBA, a bioactive compound in Boswellia extract was significantly enhanced by a fat-containing meal (e.g. fried eggs, bacon, milk etc). Fat in foods also helps improve the absorption of curcumin (a bioactive compound in turmeric root extract) in the body. Hence, taking FlexC MAX after meals would maximise its potency and efficacy.
Q: Who should take FlexC MAX?
A: FlexC MAX is highly recommended for those suffering from joint discomforts such as joint pain, stiffness, swelling or decreased range of motion. It is also beneficial for those with high risks of wear and tear on the cartilage; this includes the middle-aged and elderly, overweight individuals as well as athletes or the physically active. Besides joint pain, FlexC Max is also effective for muscle pain, strain, spasm or past history of joint injury or fractures. Since FlexC MAX supports healthy inflammatory response / immunological functions, people who suffer from inflammation-related conditions such as heart problems, allergy, asthma, inflammation of digestive tract, etc can also benefit from taking to FlexC MAX.
Q: How effective is FlexC MAX?
A: The efficacy of FlexC MAX has been proven in multiple clinical trials. Boswellia reduced body ache up to 234%. A combination of Curumin C3 Complex® and BioPerine® reduced joint pain by 38%, stiffness by 85% and increased mobility by 41% in patients with osteoarthritis. These improvements were noticed when the extracts were studied individually. Hence, the combined formulation and synergistic effects of all extracts in FlexC MAX is expected to support greater improvements. Most users could feel the difference within 3 days, though this may vary between individuals.
Research-proven Health Benefits of Key Ingredients
1) Support healthy inflammatory response in joints
Study 1: Human leukocyte elastase (HLE) is known to trigger inflammation and pain within the joints. It has been suggested to attribute to rheumatoid arthritis due to its aggressive and destructive properties. In this in vitro study, boswellic acid AKBA was found to significantly inhibit HLE, thereby reducing joint inflammation and pain.
Study 2: In an in vitro study, Boswellia serrata extract was found to significantly reduced and normalised the production of pro-inflammatory factors - nuclear transcription factor κB (NF- κB), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cartilage cells.
Study 3: NF-ĸB is the master regulator of inflammation and plays a role in a wide variety of pathological conditions. In an in vitro study, cells were pre-incubated with curcumin for 60 minutes followed by PMA or H2O2 for 30 minutes and then tested for NF-ĸB activation. Curcumin was found to completely block PMA and H2O2-induced activation of NF-ĸB, indicating curcumin is a general suppressor of NF-ĸB activation.
Study 4: Interleukin (IL)-6 (IL6) and prostaglandin E2 (PGE2) promote inflammation and play a role in the development of rheumatoid arthritis (RA). In an in vitro study, anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated synovial cells derived from patients with rheumatoid arthritis (RA). Piperine was shown to suppress the production of IL-6 and PGE2 in a dose-dependent manner.
2) Support joint comfort & active mobility
Study 1: In a clinical trial, 49 subjects with knee osteoarthritis were orally administered either 1.125g MSM or placebo 3 times daily for 12 weeks. Taking MSM for 12 weeks showed an improvement in pain, stiffness and physical function.
Study 2: In a clinical trial, 100 patients with hip and/or knee osteoarthritis were orally administered a daily dosage of total 6g (3g twice daily) of MSM or placebo for 26 weeks. Compared to placebo, the MSM group showed significant improvement in physical symptoms and performance of daily living activities.
Study 3: In a clinical trial, 22 healthy adults were randomised to take either OptiMSM® or a placebo at 3g/day for 21 days before running a half marathon and two days after. Pain levels were recorded using a 100 mm Visual Analogue Scale (VAS) for both joint and muscle pain. OptiMSM® supplementation for 3 weeks reduced post-exercise joint and muscle pain compared to placebo.
Study 4: Boswellia serrata extract (50mg/kg) was administered to subjects for 21 days after the induction of arthritis (joint inflammation). When compared to control, Boswellia-treated group was found to be significantly decreased in edema (swelling) volume (p < 0.01). The study concluded that Boswellia serrata could be an effective adjuvant for arthritis management.
Study 5: Subjects with paw pain and arthritic ankle were orally administered piperine at 20 and 100 mg/kg/day for 8 days which resulted in significantly reduced pain and arthritic symptoms. Furthermore, piperine was also shown to significantly reduce the inflammatory area in the ankle joints. These results suggest that piperine could suppress inflammation and pain for those with joint problems.
3) Protect healthy joint structures
Patients with rheumatoid arthritis (RA) who experienced joint pain showed higher levels of serum hyaluronic acid1, suggesting an outflow from cartilaginous tissue. In this study, healthy adults with knee pain who consumed 100 mg/day of Boswellin® Super for 8 weeks showed lower levels of serum hyaluronic acid than those in the placebo group. This suggests the potential use of Boswellin® Super in protecting cartilage and alleviating pain in rheumatoid arthritis.
4) Synergistic benefits of combined ingredients
a) Curcumin and Boswellia extract
Study 1: In a randomised, double-blind, placebo-controlled trial, 201 patients with osteoarthritis (OA) were orally administered placebo, curcumin (Curcuma longa) or its combination with boswellic acid (Boswellia serrata) daily for 12 weeks and their conditions were evaluated at baseline and week 12. Both preparations resulted in a reduction of pain-related symptoms, but a combination of curcumin and boswellic acid was more effective, presumably due to synergistic effects of curcumin and boswellic acid.
Study 2: A combination of turmeric and boswellia extracts were also shown to be more effective in reducing pain than NSAID, which is a drug commonly prescribed for joint disorders.
In a clinical trial, osteoarthritic patients (age 18 - 65 years) were orally administered a CB formulation consisted of 350mg Curcuma longa (turmeric) extract (containing 70% curcumin, 17% demethoxycurcumin, 3.5% bisdemethoxycurcumin and 7.5% turmeric essential oils) and 150mg Boswellia serrata extract (containing 75% boswellic acids and 10% AKBA) in 500mg hard gelatin capsule twice daily or NSAID 100mg capsule twice daily for 12 weeks. The turmeric + Boswellia formulation was found to be more successful than for symptom scoring and clinical examination.
b) Curcumin and BioPerine®
Following oral administration, curcumin showed poor absorption resulting in low blood concentration (traces) and most of them are excreted in the faeces. However, several studies have shown that the presence of BioPerine® (an extract from black pepper fruits Piper nigrum) helped increase the bioavailability of Curcumin.
Study 1: In a test, curcumin concentration in blood serum was shown to increase significantly at 1 and 2 hours following administration of a combination of curcumin and BioPerine®.
Study 2: In a clinical trial, 10 healthy volunteers were first administered 2000 mg curcumin, followed by a two-week break before a second administration of 2000 mg of curcumin and BioPerine® (20 mg) combination. BioPerine® was shown to enhance the bioavailability of curcumin with curcumin serum concentration increased by 20-fold or 2000% compared to curcumin alone. BioPerine® inhibits metabolism and elimination in intestine and liver and thus, increasing the bioavailability of curcumin.
Ageing, unhealthy diet and lifestyle, stress, environmental factors and overactive immune response are risk factors that promote chronic inflammation – a persistent inflammation that can have long-term effects on the whole body. Pain in the body, especially at the joint, is one of the most common symptoms of chronic inflammation.
What triggers joint discomfort
Joint discomfort includes joint pain, stiffness, swelling and some degree of disability. There are several factors that can increase the risk of joint discomfort:
Ageing people are susceptible to soreness and aches when they climb stairs, walk or exercise. Natural deterioration of the body can lead to cartilage loss and inflammation which results in a vicious cycle of joint pain.
2. Daily Walking
A lifetime of walking can cause wear and tear on the cartilage, the synovium can become inflamed and thickened. This leads to cartilage loss which causes the bones to rub against each other and resulting in pain, swelling and reduced range of motion.
3. High-impact exercises
Though exercises are good for health, they can also stress the joints. High-impact exercises such as soccer, running, hockey, etc, are likely to cause injuries to the joints, leading to inflammation and damage to the cartilage. This may result in severe pain and limited range of motion.
Overweight individuals are at higher risk of developing joint problem as their weight would stress and wear out the joint cartilage, and leading to inflammation. Repeated cycles of inflammation worsens the cartilage loss and develop into chronic joint pain and swelling.
5. Oxidative Stress
Oxidative stress arises due to an imbalance between free radical production and antioxidant protection. Inflammation triggered by oxidative stress can induce cartilage damage, causing joints to become painful and stiff, with a reduced range of movement.
6. Overactive immune response
An overactive immune system will attack and damage the body’s own tissues including those in the joints, thereby leading to inflammation, swelling and pain. If left untreated, the inflammation can gradually cause permanent joint damage.
Problems Associated with Long-Term Use of
Medication for Pain Relief
Readily available nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and naproxen are the most-used medications to ease joint pain, stiffness and swelling. Nonetheless, the use of NSAIDs is commonly associated with gastrointestinal side effects (abdominal pain, ulcers, bleeding etc). Even worse, these medications have been suggested to increase the rate of cartilage breakdown and speed up the need for joint replacement (Journal of Prolotherapy 2(1): 305-322 (2010)).
Boswellin® Super Bowsellia Extract - 30% AKBA
Boswellin® Super is a standardised herbal extract from the gum resin of Boswellia serrata (Indian frankincense). Boswellia extract had been used as an anti-inflammatory and painkiller in Asian and African folk medicine for centuries. Among the four bowsellic acids in the extract, acetyl-11-keto-β-boswellic acid (AKBA) is most powerful in suppressing a pro-inflammatory enzyme to help provide relief for discomfort and support prevention of cartilage loss.
Curcumin C3 Complex® - 95% (Curcuminoids Turmeric Root Extract)
Turmeric is a spice and medicinal herb popularly used in India to treat joint inflammation, sprains, swelling caused by injury, asthma and allergic conditions. Its main active ingredient, Curcumin, is a powerful antioxidant with anti-inflammatory property. Curcumin C3 Complex® is extracted from the dried rhizomes (underground stems) of Curcuma longa (turmeric) and standardised with a minimum 95% Curcuminoids. The C3 Complex® refers to curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), collectively known as “curcuminoids”.
BioPerine® Black Pepper Extract
BioPerine® is a standardised black pepper (Piper nigrum) extract used for over 20 years to enhance the bioavailability of an ingredient. It may be co-administered with various nutrients to enhance their absorption by at least 30%.
MSM (methylsulfonylmethane) is an excellent source of sulphur, an important building block for protein synthesis and essential nutrient for the maintenance of healthy joints, tendons, ligaments and other connective tissue.
OptiMSM® is the purest, safest, and most consistent MSM in the world. It is easily assimilated into the body to support healthy cartilage, protect joints, manage swelling and pain and support a normal range of motion. OptiMSM® also helps deter the accumulation of oxidative damage developed as a result of ageing and stress.
- Joint discomfort – knee pain, neck and back pain, shoulder pain, hip pain, wrist pain, foot/ankle pain (e.g. pain, stiffness, swelling, limited range of motion)
- Muscle discomfort – Pain, strains, spasm
- Middle-aged and the elderly – pain and stiffness due to joint and cartilage degeneration
- Overweight individuals – knee pain due to weight burden on the joints
- Physically active individuals – pain from excessive training or injuries
- Inflammation-related conditions – migraine, heart issues, abdominal pain, chest pain, constant fatigue, allergies
- History of joint injuries or fractures
Contents: 60 vegecaps
1) Support joint comfort & active mobility
Study 1: In a randomised, double-blind, placebo-controlled trial, 47 healthy adults with knee pain were randomised to consume a daily capsule containing either 100 mg/day of Boswellin® Super Boswellia serrata extract or a placebo for 8 weeks. Their knee pain was evaluated at baseline, 4 weeks and 8 weeks intervention.
Compared with baseline (before treatment), the group consuming Boswellin® Super showed significant improvement in knee-pain relief after 8 weeks of intervention.
In a randomised, double-blind, placebo-controlled parallel-group clinical trial, patients suffering from mild-to-moderate knee osteoarthritis (OA) were assigned to Curcumin C3 Complex® (1500 mg/day in 3 divided doses) for 6 weeks. Each 500mg capsule contained 5mg Bioperine® to enhance oral bioavailability of curcuminoids.
Significant improvements in the pain, stiffness and physical function scores compared to baseline (before treatment) were observed. In addition, the proportion of subjects reporting no or decreased use of NSAIDs (naproxen) at the end of study was significantly greater in the Curcumin C3 Complex® group (p < 0.001), this suggests the effectiveness of curcuminoids in managing OA.
2) Support healthy inflammatory response
Leukotrienes are inflammatory molecules produced by enzyme 5-lipoxygenase (5-LO). In this in vitro study, boswellic acid AKBA was found to inhibit 5-LO inflammatory activity, thereby suppressing the production of leukotrienes and inflammatory response.
3) Provide antioxidant protection to joints
Besides “mechanical stress”, oxidative stress also contributes to the development and progression of osteoarthritis (OA).
Curcuminoid is a strong antioxidant with potent anti-inflammatory property, thus, may be helpful in the treatment of OA. In a randomised, double-blind and placebo-controlled trial, 40 patients with mild-to-moderate knee osteoarthritis were administered either 3 capsules of Curcumin C3 Complex® formulation (500 mg Curcumin C3 Complex® and 5 mg BioPerine® combination per capsule) or placebo daily for a period of 6 weeks. Supplementation with Curcumin C3 Complex® - BioPerine® resulted in significant improvements in systemic oxidative stress biomarkers, which further validates antioxidant effects of curcuminoids in OA. Curcumin C3 Complex® - BioPerine® reduces oxidative stress in osteoarthritis
4) Protect healthy joint structures
In this test, osteoarthritis was induced into knee joints of subjects. Consumption of a diet containing Boswellia serrata (BS) extract (100 and 200 mg/kg) for 35 days significantly suppressed the development and severity of osteoarthritis in subjects, as shown by decreased levels of factors (MMP-3, MMP-9 and MMP-13) that degrade the cartilage. This study suggests that BS extract may be a potential therapeutic treatment for degenerative osteoarthritis.
|60 veggie caps|