Bioactive Organic LingZhi Ultra

Research proven health benefits of Bioactive Organic LINGZHI ULTRA:

The following are extracted from published clinical studies, in-house studies, and/or case studies and are for reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to replicate the same results produced in the studies. This information is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult your physician or other qualified healthcare providers. Any statements or claims made have not been evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any disease.

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1. Boost immune system

Reishi or Lingzhi (Ganoderma lucidum) is a well-known medicinal mushroom in China and Japan for its immunomodulatory and anti-tumor effects. It provides a broad spectrum of immunostimulating activities, as well as anti-inflammatory and anti-allergic activities.

Study 1: Cancer patients
In this clinical trial, 34 advanced-stage cancer patients were orally administered with 1800 mg Ganoderma lucidum polysaccharide (GLPS), 3 times daily before meals for 12 weeks. Treatment for 12 weeks resulted in a significant increase in interleukin-2 (IL-2) and interferon-gamma (IFN-ɣ), which are cytokines responsible to induce and modulate an array of immune responses. Furthermore, treatment with GLPS also significantly enhanced activity of natural killer (NK) cells, which constitutes the body’s frontline defense system to protect against tumors and fight against infections. These findings suggest immune-boosting activity of GLPS on patients with advanced-stage cancer. 

Study 2: Healthy individuals
In this clinical trial, male football players on a 28-day “living high-training low” (LHTL) trial were orally administered placebo or Ganoderma lucidum for 6 weeks and their CD4+/CD8+ ratio were determined. CD4+/CD8+ ratio is a reflection of immune health. A normal ratio is between 1 and 4. This ratio tends to decrease if the immune system’s defense against pathogens become weaker.

Due to simultaneous stimuli of physical activity and exposure to hypoxia (low oxygen), a significant decrease in CD4+/CD8+ ratio following the 28-day trial compared to the baseline was observed in placebo group. Nonetheless, oral administration of G. lucidum could help ameliorate the variation of the CD4+/CD8+ in LHTL training. These findings suggest that G. lucidum support healthy immunity of athletes exposed to stressful conditions. 

2. Fight fatigue

Chronic fatigue syndrome is a group of physical and mental disorders that can reduce quality of life and daily routine of the sufferers. Currently, there is no medical treatment available for the disorders. In Traditional Chinese Medicine, body fatigue, mental fatigue, weakness and stress are indications of Qi and blood deficiency. Reishi or Lingzhi (Ganoderma lucidum) is commonly used to nourish and tonify Qi and blood. Besides, Reishi could also help manage insomnia, dream-disturbed sleep and anxiety.

Study 1:
In this clinical trial, 50 volunteers with chronic fatigue syndrome were orally administered placebo or daily dose of 2g (0.5g four times a day) Ganoderma lucidum extract before meals and bedtime for 12 weeks. The volunteers were then asked to respond to SF-12 questionnaires for quality of life and score the levels of fatigue and VAS, before and 4, 8 and 12 weeks after the first dose. Compared to placebo, G. lucidum extract resulted in a significant increase in quality of life and a decrease in VAS scores. Lower VAS scores indicate better quality of life. In addition, satisfaction of volunteers with 12-week G. lucidum extract was significantly higher than those taking placebo. These findings suggest that G. lucidum could be potentially effective in the treatment of fatigue and improve quality of life in those suffering from chronic fatigue. 

3. Potentially protect against abnormal cell growth

Clinical research has shown the beneficial effects of Reishi or Lingzhi (Ganoderma lucidum) as an alternative adjuvant therapy in cancer patients, which could be attributed to its stimulatory effect on the host immune system and enhancement in tumor response. Polysaccharides and triterpenoids are the main components of Reishi that have anti-tumor activating properties on different kinds of immune cells (macrophages, T lymphocytes, natural killer cells, dendritic cells), as well as initiating cytokine production.

Study 1: Colorectal tumor
In this clinical trial, patients with colorectal tumor (adenoma) were orally administered Ganoderma lucidum mycelia extract(1.5 g/day) for 12 months and cancer-preventive effects were determined. Administration of G. lucidum extract resulted in decreased number and size of adenomas, whereas control group observed an increment of both number and size of
adenomas. These findings suggest that G. lucidum could potentially suppress the development of colorectal adenomas in the large intestines. 

Study 2: Prostate cancer
In this in vitro study, the effects of Ganoderma lucidum polysaccharides on human prostate cancer cells were investigated. Results showed that G. lucidum polysaccharides suppressed prostate cancer cell growth and migration. These findings suggestthat G. lucidum polysaccharides may act as a tumor suppressor with potential applications in prostate cancer therapy. 

4. Support healthy blood lipids

Reishi or Lingzhi (Ganoderma lucidum) has been consumed for its broad medicinal properties in Asia for over 2000 years. It is said to influence the heart and is becoming increasingly popular in western countries as a complementary therapy for cardiovascular health.

Study 1:
In this clinical trial, 26 patients with borderline elevations of blood pressure and/or cholesterol were orally administered 1.44g Ganoderma lucidum daily or placebo for 12 weeks. Compared to baseline, administration of G. lucidum resulted in a decrease of triglyceride and increase of HDL-cholesterol, but not with placebo, suggesting its beneficial effects to blood lipids and cardiovascular health.

5. Support healthy blood glucose

Reishi or Lingzhi (Ganoderma lucidum) extracts have been recognized as an alternative adjuvant treatment for diabetes. Numerous biologically active compounds of Reishi, including polysaccharides, proteoglycans, proteins and triterpenoids have been shown to have blood glucose lowering effects. Animal test in mice showed that Reishi polysaccharides increased plasma insulin levels and decreased plasma sugar levels, demonstrating its hypoglycemic activity.

Study 1:
In this clinical trial, 71 patients with type 2 diabetes were orally administered Ganoderma lucidum polysaccharides or placebo at 1800 mg 3 times daily for 12 weeks. Compared to baseline, G. lucidum polysaccharides significantly decreased haemoglobin A1c (HbA1C), which indicates the average blood glucose levels over the past 3 months. In addition, patients
treated with G. lucidum polysaccharides also showed a significant decrease in postprandial plasma glucose (PPG) levels, which is a measure of blood glucose level an hour or 2 after a meal. The lower HbA1C and PPG, the better the blood glucose control. These parameters did not change or slightly increased in patients administered with placebo. These findings suggest that G. lucidum polysaccharides are efficacious in lowering blood glucose levels. 

6. Improve liver health

Reishi or Lingzhi (Ganoderma lucidum) is widely known in the treatment of chronic liver disease with little or no side effects, attributed to its antioxidant, anti-inflammatory and hepatoprotective properties. Among many bioactive compounds in Reishi, triterpenoids and polysaccharides in Reishi have been proven to suppress fatty liver, hepatitis (liver inflammation) and liver fibrosis.

Study 1:
In this clinical trial, 42 healthy middle-aged (40-54 years old) volunteers with mild liver dysfunction (elevated GOT and GPT, as well as fatty liver) were orally administered Ganoderma lucidum after lunch or dinner for 6 months. Consumption of G.lucidum significantly improved the total antioxidant capacity (TEAC) and reduced oxidative stress markers TBARS and
8-OH-dG. Ultrasonic examination also showed a notable alteration on hepatic condition by reversing from mild fatty liver condition to normal condition. These findings suggest the antioxidation and liver protective nature of G. lucidum by effectively curbing oxidative stress.

Study 2:
Liver fibrosis is the formation of an abnormally large amount of scar tissue in the liver, when the liver attempts to repair and replace damaged cells. Unlike healthy liver cells, scar tissue cells cannot function appropriately or self-repair or. As a result, fibrosis can reduce overall liver function and diminish the liver’s ability to regenerate. In this animal test, rats were induced to have liver fibrosis by gamma irradiation and CCl4, and oral co-administration of 110mg/kg Ganoderma lucidum. G. lucidum provided remarkably liver protection as seen by significant decrement in liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). An elevation of liver enzymes may be a sign of a liver problem. In addition, G. lucidum also decreased levels of malondialdehye (MDA), an indicator of liver damage, as well as increased antioxidant enzyme (GSH, SOD) activities. Microscopical examination also revealed suppression of G. lucidum on liver fibrosis. These findings support protective effects of G. lucidum against liver fibrosis. 

7. Improve gastrointestinal health

Gastric ulcers are open sores that develop on the stomach linings. The symptoms of a stomach ulcer include burning pain in the abdomen, indigestion, poor appetite. The polysaccharide fractions from several medicinal herbs have been shown to have anti-ulcer effects against ulcers. Polysaccharides from Reishi or Lingzhi (Ganoderma lucidum) have also been
shown to suppress gastric mucosal lesions in an animal test.

Study 1:
In this animal test, rats were induced experimental acute gastric ulcer and treated once with injections of Ganoderma lucidum pharmacopuncture (GLP). The stomach from the rats were then collected and analysed. Results showed that GLP promoted wound healing of the acute gastric ulcers. In addition, GLP reduced BAX (a cell death marker) and increased
TGF β1, which helped promote recovery in the injured mucosa (stomach lining) of the gastric ulcer. These findings suggest that G. lucidum can provide significant protection to the gastric mucosa against an acute gastric ulcer. 

8. Support restful sleep

Reishi or Lingzhi (Ganoderma lucidum) improves insomnia naturally without any side effects of sleeping pills. It promotes restful sleep by strengthening function pineal gland (which makes “sleep hormone” melatonin), balances melatonin levels and modulate brain activity during sleep.

Study 1:
In this animal test, rats administered with Ganoderma lucidum extract showed significant decreased sleep latency (amount of time from being fully awake to sleeping) and increased sleeping time. In addition, significant effect was also observed on delta activity during non-REM sleep. These findings suggest the beneficial effects of G. lucidum extract on those having sleep disorders (Pharmacol Biochem Behav. 86(4): 693-698 (2007)).

9. Improve gut microbiota

Mushroom polysaccharides from Reishi or Lingzhi (Ganoderma lucidum) could acts as prebiotics and contribute to health benefits in part by modulating gut microbiota. Reishi supplementation has shown prebiotic ability in increasing the number of beneficial bacteria, such as Bifidobacteria, Lactobacillus etc. In addition, a recent study showed that a Reishi extract is a promising tool to tackle obesity by modulating the gut microbiota.

Study 1:
In this animal test, mushroom polysaccharides derived from fruiting bodies (GL-F) and mycelia (GL-M) of Ganoderma lucidum were administered daily to 6-week old mice for 15 days and gut microbiota was evaluated using ERIC-PCR and 16S amplicon sequencing. The polysaccharides significantly (p < 0.01) remodeled gut microbiota compositions. Bacteria that are known for anti-obesity, SCFA-producer, polysaccharides/xylan degradation, and lactic acid production were significantly (p < 0.05) abundant in mice treated with polysaccharides. In brief, the health promoting effects of G. lucidum could be attributed to its polysaccharides, which act as prebiotics to modulate gut microbiota composition. 

10. Improve physical fitness in women with fibromyalgia

Fibromyalgia is a chronic disease characterized by widespread body pain, fitness, poor physical conditions, which are accompanied by non-restorative sleep, fatigue, memory and mood issues. Studies hypothesized that oxidative stress may contribute to the development of fibromyalgia. Given the potential benefits of Reishi or Lingzhi (Ganoderma lucidum) to provide antioxidant protection and increase vital energy, it could potentially improve physical fitness in patients suffering from fibromyalgia.

Study 1:
In this clinical trial, 64 women with fibromyalgia were orally administered 6g of Ganoderma lucidum per day for 6 weeks and different fitness tests were conducted to evaluate physical fitness. Administration of G. lucidum for 6 weeks significantly improved aerobic endurance (maximum distance walked in 6 minutes), lower body flexibility (chair-sit-and-reach test) and velocity (speed of walking for 20 meters). These findings imply that G. lucidum could be used to enhance physical performance of the patients suffering from fibromyalgia.